IMPACT OF ROSEMARY (ROSMARINUS OFFICINALIS) EXTRACTS ON TRYPANOSOMA EVANSI IN EXPERIMENTALLY INFECTED RATS | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Article 4, Volume 51, Issue 2, August 2021, Page 257-266 PDF (966.01 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jesp.2021.192721 | ||||
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| Authors | ||||
| SARA SAMY ALASRAG1; SAFAA MOHAMED BARGHASH1; HODA ABDEL-HALIM TAHA2; AMEEN A. ASHOUR2 | ||||
| 1Parasitology Unit, Animal Health Department, Desert Research Center, Cairo, P.O. Box 11753 | ||||
| 2Department of Zoology, Faculty of Science, Ain Shams University, 11566, Egypt | ||||
| Abstract | ||||
| This study evaluated the activity of rosemary (Rosmarinus officinalis) plant extracts on Trypanosoma evansi infection compared to diminazene aceturate drug (DA). Eight extracts were prepared at concentrations of 4, 10, & 20mg/ml (four from leaves and four from stem bark) of the rosemary plant collected from Matrouh Governorate. Petroleum ether, ethyl acetate, ethyl alcohol, and distilled water were used in order of increasing polarity. Phytoscreening of those extracts and their toxicity were assessed. In vitro & in vivo studies evaluated T. evansi viability post treatment and the efficiency of different extracts. Also, for potential hematological and biochemical abnormalities that may be associated with the administration of different treatments. The results showed that the phytochemical screening showed significant differences (p≤0.05) between leaves and stem bark components. Extract of 20mg/ml in vitro affected activity of T. evansi more than others but, less than diminazene aceturate without acute toxicity. Statistical analysis corroborated anti-trypanosomal activity-specifically correlated to treatment based on solvent type and plant part extracted. In vivo results showed a significant reduction in infectioninduced alterations in treated groups compared to untreated healthy group. Some extracts did not achieve complete restoration of some selected biochemical indices to a pre-infection state. | ||||
| Keywords | ||||
| Trypanosoma evansi; Rosemary extracts; In vitro; In vivo; Organic solvents; Rats | ||||
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