Rapid and Green Chemistry Catalysis in Synthesis of Hexahydroquinazolinones and Cyclopenta, Cyclohepta[d]Pyrimidinones with Prediction of Biological Activity via PASS INET
M. M. El-Saghier, A., A. Ahmed, E., M. A. Mahmoud, A. (2015). Rapid and Green Chemistry Catalysis in Synthesis of Hexahydroquinazolinones and Cyclopenta, Cyclohepta[d]Pyrimidinones with Prediction of Biological Activity via PASS INET. EKB Journal Management System, 1(1), 16-26. doi: 10.12785/jpac/010102
Ahmed M. M. El-Saghier; Eman A. Ahmed; Ahmed M. A. Mahmoud. "Rapid and Green Chemistry Catalysis in Synthesis of Hexahydroquinazolinones and Cyclopenta, Cyclohepta[d]Pyrimidinones with Prediction of Biological Activity via PASS INET". EKB Journal Management System, 1, 1, 2015, 16-26. doi: 10.12785/jpac/010102
M. M. El-Saghier, A., A. Ahmed, E., M. A. Mahmoud, A. (2015). 'Rapid and Green Chemistry Catalysis in Synthesis of Hexahydroquinazolinones and Cyclopenta, Cyclohepta[d]Pyrimidinones with Prediction of Biological Activity via PASS INET', EKB Journal Management System, 1(1), pp. 16-26. doi: 10.12785/jpac/010102
M. M. El-Saghier, A., A. Ahmed, E., M. A. Mahmoud, A. Rapid and Green Chemistry Catalysis in Synthesis of Hexahydroquinazolinones and Cyclopenta, Cyclohepta[d]Pyrimidinones with Prediction of Biological Activity via PASS INET. EKB Journal Management System, 2015; 1(1): 16-26. doi: 10.12785/jpac/010102

Rapid and Green Chemistry Catalysis in Synthesis of Hexahydroquinazolinones and Cyclopenta, Cyclohepta[d]Pyrimidinones with Prediction of Biological Activity via PASS INET

Journal of Pharmaceutical and Applied Chemistry
Volume 1, Issue 1, May 2015, Page 16-26  XML PDF (716.31 K)
Document Type: Original Article
DOI: 10.12785/jpac/010102
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Authors
Ahmed M. M. El-Saghier; Eman A. Ahmed; Ahmed M. A. Mahmoud
Chemistry Department, Faculty of Science, Sohag University
Abstract
Ceric Ammonium Nitrate (CAN), turns out to be commercially available, efficient and mild catalyst for synthesis of polyhydro-2Hcycloalka[d]pyrimidinones and hexahydroquinazolinones in few minutes. Accompanied with Predictions of the activity spectra of some selected compounds using 
PASS INET. at Pa > 50%, showing high probability of Protein kinase (CK1) inhibitor and Alpha7 nicotinic receptor agonist. However Cycloheptene systems 
showed some important targets including, Insulin growth factor agonist, and Acetylcholine nicotinic agonist and Tumour necrosis factor agonist.
Keywords
Ceric Ammonium Nitrate (CAN); cycloalka[d]pyrimidinones hexahydroquinazolinones; Greeen Chemistry; Pass Inet
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