Synthesis and Cytotoxic Activity of New Substituted Pyrazolo[3,4-b]pyridine Derivatives and Their Acyclic Nucleoside Analogs
Hawata, M., El-Essawy, F., El-Sayed, W., El-Bayaa, M. (2022). Synthesis and Cytotoxic Activity of New Substituted Pyrazolo[3,4-b]pyridine Derivatives and Their Acyclic Nucleoside Analogs. EKB Journal Management System, 65(3), 161-169. doi: 10.21608/ejchem.2021.90009.4302
Mohamed Abdallah Hawata; Farag El-Essawy; Wael A. El-Sayed; Mohamed El-Bayaa. "Synthesis and Cytotoxic Activity of New Substituted Pyrazolo[3,4-b]pyridine Derivatives and Their Acyclic Nucleoside Analogs". EKB Journal Management System, 65, 3, 2022, 161-169. doi: 10.21608/ejchem.2021.90009.4302
Hawata, M., El-Essawy, F., El-Sayed, W., El-Bayaa, M. (2022). 'Synthesis and Cytotoxic Activity of New Substituted Pyrazolo[3,4-b]pyridine Derivatives and Their Acyclic Nucleoside Analogs', EKB Journal Management System, 65(3), pp. 161-169. doi: 10.21608/ejchem.2021.90009.4302
Hawata, M., El-Essawy, F., El-Sayed, W., El-Bayaa, M. Synthesis and Cytotoxic Activity of New Substituted Pyrazolo[3,4-b]pyridine Derivatives and Their Acyclic Nucleoside Analogs. EKB Journal Management System, 2022; 65(3): 161-169. doi: 10.21608/ejchem.2021.90009.4302

Synthesis and Cytotoxic Activity of New Substituted Pyrazolo[3,4-b]pyridine Derivatives and Their Acyclic Nucleoside Analogs

Egyptian Journal of Chemistry
Article 15, Volume 65, Issue 3, March 2022, Page 161-169  XML PDF (600.96 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2021.90009.4302
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Authors
Mohamed Abdallah Hawata email 1; Farag El-Essawy2; Wael A. El-Sayedorcid 3; Mohamed El-Bayaa4
1Faculty of science menoufia university shebien ElKoom Egypt
2Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Kom 32511, Egypt.
3Photochemistry Department, National Research Centre, Dokki, Cairo, Egypt
4Photochemistry Department, National Research Centre
Abstract
As an important strategy, including incorporation of more than active core in one molecule, for finding potent candidates against cancer cells, a number of functionalized pyrazolopyridin derivatives linked to oxadiazole, dioxolane, acyclic sugar and fluorene ring systems, were synthesized through heterocyclization reactions. The derived sugar hydrazone and the corresponding acyclic C-nucleoside analog in addition to acyclic N-nucleoside were also prepared. The behavior of the afforded compounds as possible cytotoxic agents against human HTC116 and MCF7 cancer cells was investigated and the results showed that compounds 11-13 showed the highest activities against the two cancer cells. Other compounds revealed a type of selectivity toward one cancer cell while the activity was relatively lost against the other cancer cell line.
Keywords
pyrazolopyridin; sugar; hydrazone; oxadiazole; acyclic nucleoside; anticancer
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