Age Combination of Living Donor and Recipient of Kidney Transplantation and Its Impact on Transplant Outcome; a retrospective study
galalah, I., Elokely, A., Sally, S., salem, I. (2022). Age Combination of Living Donor and Recipient of Kidney Transplantation and Its Impact on Transplant Outcome; a retrospective study. EKB Journal Management System, 28(6), 1443-1453. doi: 10.21608/zumj.2021.86974.2291
ibrahim galalah; Amir Mohammed Elokely; Samir Mohamed Sally; ibrahim mohamed salem. "Age Combination of Living Donor and Recipient of Kidney Transplantation and Its Impact on Transplant Outcome; a retrospective study". EKB Journal Management System, 28, 6, 2022, 1443-1453. doi: 10.21608/zumj.2021.86974.2291
galalah, I., Elokely, A., Sally, S., salem, I. (2022). 'Age Combination of Living Donor and Recipient of Kidney Transplantation and Its Impact on Transplant Outcome; a retrospective study', EKB Journal Management System, 28(6), pp. 1443-1453. doi: 10.21608/zumj.2021.86974.2291
galalah, I., Elokely, A., Sally, S., salem, I. Age Combination of Living Donor and Recipient of Kidney Transplantation and Its Impact on Transplant Outcome; a retrospective study. EKB Journal Management System, 2022; 28(6): 1443-1453. doi: 10.21608/zumj.2021.86974.2291

Age Combination of Living Donor and Recipient of Kidney Transplantation and Its Impact on Transplant Outcome; a retrospective study

Zagazig University Medical Journal
Article 30, Volume 28, Issue 6, November 2022, Page 1443-1453  XML PDF (295.69 K)
Document Type: Original Article
DOI: 10.21608/zumj.2021.86974.2291
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Authors
ibrahim galalah email 1; Amir Mohammed Elokely2; Samir Mohamed Sally1; ibrahim mohamed salem3
1department of hemodialysis and transplantation, urology and nephrology center, faculty of medicine, Mansoura University, Mansoura City, Egypt
2internal medicine department,faculty of medicine,zagazig university,zagazig,egypt
3Internal Medicine Department, Faculty of Medicine, Zagazig University, Sharkia Egypt
Abstract
Background: we evaluated the impact of combined age of living donor and recipient on kidney transplant outcome.

Methods: Retrospective cohort study on 3068 kidney transplant recipients at Mansoura Urology and Nephrology Centre between March 1976 and December 2019, divided into four groups according to age, group I: recipients < 40 years from donors < 40 years (1665 KTrs), group II: recipients < 40 years from donors ≥ 40 years (932 KTrs), group III: recipients ≥ 40 years from donors < 40 years (320 KTrs) and group IV: recipients ≥40 years from donors ≥ 40 years (151 KTrs).

Results: Incidence of rejection was higher in group I and lower in group VI. Incidence of post-transplant hypertension, diabetes, hepatic impairment and malignancy was higher in group III and lower in group II (p value: 0.0001). Overall, 5, 10 and 15 years graft survival was better in group IV and worse in group II (p value: 0.013). 5, 10 and 15 years' patient survival was better in group II and worse in group III (p value: 0.0001).

Conclusions: Young donor to young recipient transplantation was associated with higher incidence of rejection. Old donor to young recipient transplantation was associated with the best patient survival, lower incidence of post-transplant medical complications but the worst graft survival. Young donor to old recipient transplantation was associated with higher incidence of post-transplant medical complications and worst patient survival. Old donor to old recipient transplantation was associated with the lowest incidence of rejection and the best graft survival.
Keywords
kidney transplantation; age; graft survival
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