IMPACT OF CURCUMIN AND VIRGIN OLIVE OIL AGAINST LEAD ACETATE-INDUCED GENETIC VARIATION IN THE MAJOR HISTOCOMPATIBILITY COMPLEX REGION IN MICE

Allam, Mohammad; Aly, Fayza M.; Mar&#039;ie, Zeinab A.

doi:10.21608/ejz.2021.88079.1063

	IMPACT OF CURCUMIN AND VIRGIN OLIVE OIL AGAINST LEAD ACETATE-INDUCED GENETIC VARIATION IN THE MAJOR HISTOCOMPATIBILITY COMPLEX REGION IN MICE
Egyptian Journal of Zoology
Article 17, Volume 76, Issue 76, December 2021, Page 66-75 PDF (397.21 K)
Document Type: Original Research Papers
DOI: 10.21608/ejz.2021.88079.1063
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Authors
Mohammad Allam ¹; Fayza M. Aly¹; Zeinab A. Mar'ie¹^{, 2}
¹Zoology Department, Faculty of Science, South Valley University, Qena, Egypt
²Science Department, Faculty of Education, South Valley University, Hurghada, Red Sea, Egypt
Abstract
Lead acetate – which results in significant damage to the genetic structure of living organisms – is found in many sources that humans use daily. Histocompatibility complex (MHC) genes in the vertebrate play a critical role in immune responses, and are highly polymorphic. Virgin olive oil (VOO) and curcumin are natural compounds having several healthy features including antigenotoxic activities. The present study aimed for determining the effects of VOO and curcumin (versus ZnCl₂, as an antioxidant agent) on Mhc genetic variation of renal tissues of lead acetate-treated mice by using the microsatellite loci. Thirty male albino Swiss mice (Mus musculus) were randomly allotted into 5 groups (n = 6): group “1”, the control group; groups “2–5” that received orally lead acetate (400 mg/kg body weight, by gavage for 15 consecutive days) + either distilled water (orally), or ZnCl₂ (4 mg/kg body weight, intraperitoneally injected), or curcumin (500 mg/kg body weight, orally), or VOO (8 mL/kg body weight, orally) for additional 15 consecutive days, respectively. Comparing to the control group, the 2^nd and the 4^th groups showed high polymorphism value (17%) and (21%), respectively; while the 3^rd and 5^th groups showed low polymorphism value (12%) and (15%), respectively, in Mhc genes. The obtained data illustrated the usefulness of virgin olive oil, as compared with the curcumin, in limiting Mhc genetic variation induced by lead acetate in mice.
Keywords
Curcumin; Genetic variation; Lead acetate; Mice Mhc; Virgin olive oil


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