VALUE OF SERUM ALPHA L FUCOSIDASE LEVEL AS A PROGNOSTIC BIOMARKER FOR HEPATOCELLULAR CARCINOMA BEFORE AND AFTER CHEMO-EMBOLIZATION AND RADIO-FREQUENCY, A PROSPECTIVE STUDY | ||||
| Journal of the Egyptian Society of Parasitology | ||||
| Article 17, Volume 51, Issue 2, August 2021, Page 377-384 PDF (783.41 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jesp.2021.193321 | ||||
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| Authors | ||||
| AHMED SAMIR ABO HALIMA; MARCEL WILLIAM KEDDEAS; HANY HAROUN KAISAR | ||||
| Department of Gastroenterology and Hepatology, Faculty of Medicine, Ain Shams University, Cairo 11211, Egypt | ||||
| Abstract | ||||
| Because hepatocellular carcinoma (HCC) is a complex disease with multiple risk pathogenic mechanisms due to misdiagnosis with a single biomarker. A combination of biomarkers may be more valuable for the diagnosis, staging and prognosis of HCC. In the near future, identifying non-invasive and cost-effective biomarkers for early diagnosis and personalized treatment of HCC will be one of the most promising fields of biomarker research. This study assessed the alpha L fucosidase (AFU) value as a prognostic biomarker in patients with HCC before and after chemo-embolization and radio-frequency. A total of 60 subjects were subdivided into 3 groups: GI: 30 HCC patients underwent interventional management (chemo-embolization or radiofrequency), GII: 20 liver cirrhosis (LC) patients and GIII: 10 cross-matched individuals as control The results showed that plasma AFU had significantly higher diagnostic performance in HCC diagnosis than alpha fetoprotein (AFP) at a cut off value of > 2.5u/l, with sensitivity 100%, specificity 95%, positive predictive value (PPV) 96.8%, negative predictive value (NPV) 100% and diagnostic accuracy 98%. Basal pre-intervention AFU) had significantly high diagnostic performance to predict HCC recurrence after intervention at a cut off value of > 12.5u/l with sensitivity 100%, specificity 92%, PPV, 71.4%, NPV 100% and diagnostic accuracy 93.3%. Postintervention AFU had significant moderate diagnostic performance in predicting recurrence of HCC at cut off value of > 7.5u/l with sensitivity 80%, specificity 92%, positive predictive value (PPV) 66.7%, negative predictive value (NPV) 95.8% & diagnostic accuracy 90%. | ||||
| Keywords | ||||
| Egypt; Patients; Alpha L Fucosidase; Alphafetoprotein; HCC; Chemo-embolization | ||||
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