Evaluation of Efficacy and Safety Topical 5-Fluorouracil 0.5% in Treatment of Resistant Vitiligo [Alone or After Microneedling]; A pilot Study
Galal, S., Ali, M., Elzeiny, F. (2021). Evaluation of Efficacy and Safety Topical 5-Fluorouracil 0.5% in Treatment of Resistant Vitiligo [Alone or After Microneedling]; A pilot Study. EKB Journal Management System, 3(4), 1803-1810. doi: 10.21608/ijma.2021.89242.1347
Sara Ahmed Galal; Moshiraly Mohammed Ali; Fatma Refaat Elzeiny Elzeiny. "Evaluation of Efficacy and Safety Topical 5-Fluorouracil 0.5% in Treatment of Resistant Vitiligo [Alone or After Microneedling]; A pilot Study". EKB Journal Management System, 3, 4, 2021, 1803-1810. doi: 10.21608/ijma.2021.89242.1347
Galal, S., Ali, M., Elzeiny, F. (2021). 'Evaluation of Efficacy and Safety Topical 5-Fluorouracil 0.5% in Treatment of Resistant Vitiligo [Alone or After Microneedling]; A pilot Study', EKB Journal Management System, 3(4), pp. 1803-1810. doi: 10.21608/ijma.2021.89242.1347
Galal, S., Ali, M., Elzeiny, F. Evaluation of Efficacy and Safety Topical 5-Fluorouracil 0.5% in Treatment of Resistant Vitiligo [Alone or After Microneedling]; A pilot Study. EKB Journal Management System, 2021; 3(4): 1803-1810. doi: 10.21608/ijma.2021.89242.1347

Evaluation of Efficacy and Safety Topical 5-Fluorouracil 0.5% in Treatment of Resistant Vitiligo [Alone or After Microneedling]; A pilot Study

International Journal of Medical Arts
Article 7, Volume 3, Issue 4, October 2021, Page 1803-1810  XML PDF (1.47 MB)
Document Type: Original Article
DOI: 10.21608/ijma.2021.89242.1347
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Authors
Sara Ahmed Galal email orcid 1; Moshiraly Mohammed Ali1; Fatma Refaat Elzeiny Elzeiny2
1Department of Dermatology and Venereology, Faculty of Medicine for Girls, Al-Azhar University, Egypt
2Third Doctor in the Medical Organization [for Girls], Al-Azhar University, Cairo, Egypt
Abstract
Background: Vitiligo is a chronic acquired disorder characterized by the depigmented macules. There are many treatment options, but the response is variable and unsatisfactory. Topical 5-fluorouracil used in many dermatological diseases but, this is the first study to date that use 0.5% concentration in vitiligo treatment.
The Aim of The Work: This study evaluates efficacy and safety topical 5-fluorouracil in 0.5% concentration in treatment of resistant vitiligo either alone or after microneedling.
Subject and Methods: 30 patients with resistant vitiligo were enrolled into the study; we studied only 2 patches in every patient. The first patch treated with one session of microneedling followed by topical 5-fluorouracil 0.5% once daily for 2 weeks. The second patch treated with topical 5-fluorouracil 0.5% only for 2 weeks, then follow up of both patches for 3 months.
Results: Excellent response achieved in 46.7% of the patches treated with microneedling followed by topical 5-fluorouracil 0.5%, while only in 23.3% of the patches treated with topical 5-fluorouracil 0.5% alone. There was no significant difference between both groups regarding response, despite this the degree of improvement was higher in combined treatment.
Conclusion: Topical 5-fluorouracil 0.5% is an effective and safe in treatment of resistant vitiligo and combined therapy increases the efficacy.  
Keywords
5-fluorouracil 0.5%; Microneedling; Pigmentation; Vitiligo
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