The relation of systemic lupus erythematosus activity and histopathology of renal biopsy | ||||
Sohag Medical Journal | ||||
Article 13, Volume 25, Issue 2, April 2021, Page 100-105 PDF (761.26 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/smj.2021.74553.1248 | ||||
View on SCiNiTO | ||||
Authors | ||||
Rana Saad-eldin 1; Nehal Fathy2; Afaf Taha El-Nashar 3; Esam Mohammed Abo Al-Fadl4 | ||||
1Department of rheumatology and rehabilitation, Sohag faculty of medicine, Sohag university | ||||
2Rheumatology & rehabilitation department , assiut faculty of medicine , assiut university | ||||
3Department of Pathology, Faculty of Medicine, Sohag | ||||
4Department of Internal Medicine and Department of Rheumatology, Rehabilitation and Physical medicine,Faculty of Medicine- Sohag University. | ||||
Abstract | ||||
Background: About 50% of patients with systemic lupus erythematosus (SLE) develop lupus nephritis during the course of their disease. Up to 10% of these patients reach the end-stage renal disease. Purpose: Detection of the relationship between the activity of systemic lupus erythematosus (SLE) and histopathology of renal biopsy. Patients and methods: This study is cross- sectional and observational. It included one hundred Egyptian patients with SLE according to the 2015 ACR/SLICC Revised criteria. SLE Disease Activity Index (SLEDAI) and renal biopsy were done to all patients in addition to the routine investigations. Results: Of the one hundred patients; 9 were males and 91 were females with a mean age ± standard deviation of 32.28 ± 9.59 years and a median of 31.5 years. The mean value SLEDAI was 11.92 ± 3.92. Lupus nephritis (LN) was found in 85 patients (85%) with 5 patients (5%) having class 1, 73 patients (73%) having class 2 and 7 patients (7%) having class3 LN. Conclusion: Ther relationship between the SLEDAI score and the histopathological study of renal biopsy in patients with SLE is strong and significant with a mean value of SLEDAI directly proportional to the class of LN. | ||||
Keywords | ||||
lupus nephritis; renal biopsy; SLEDAI score | ||||
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