Impact of dietary supplementation of vitamin E (alpha-tocopherol acetate) on genetic expression of inflammatory cytokines and growth efficiency of broiler chickens
Elshawash, A., Elgendy, F., Khalifa, O., Hemeda, S. (2021). Impact of dietary supplementation of vitamin E (alpha-tocopherol acetate) on genetic expression of inflammatory cytokines and growth efficiency of broiler chickens. EKB Journal Management System, 40(2), 202-206. doi: 10.21608/bvmj.2021.75450.1405
aya Elshawash; Fatma Elgendy; Olla Khalifa; Shabaan Abd-Ellatif Hemeda. "Impact of dietary supplementation of vitamin E (alpha-tocopherol acetate) on genetic expression of inflammatory cytokines and growth efficiency of broiler chickens". EKB Journal Management System, 40, 2, 2021, 202-206. doi: 10.21608/bvmj.2021.75450.1405
Elshawash, A., Elgendy, F., Khalifa, O., Hemeda, S. (2021). 'Impact of dietary supplementation of vitamin E (alpha-tocopherol acetate) on genetic expression of inflammatory cytokines and growth efficiency of broiler chickens', EKB Journal Management System, 40(2), pp. 202-206. doi: 10.21608/bvmj.2021.75450.1405
Elshawash, A., Elgendy, F., Khalifa, O., Hemeda, S. Impact of dietary supplementation of vitamin E (alpha-tocopherol acetate) on genetic expression of inflammatory cytokines and growth efficiency of broiler chickens. EKB Journal Management System, 2021; 40(2): 202-206. doi: 10.21608/bvmj.2021.75450.1405

Impact of dietary supplementation of vitamin E (alpha-tocopherol acetate) on genetic expression of inflammatory cytokines and growth efficiency of broiler chickens

Benha Veterinary Medical Journal
Article 40, Volume 40, Issue 2, July 2021, Page 202-206  XML PDF (301.73 K)
Document Type: Original Article
DOI: 10.21608/bvmj.2021.75450.1405
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Authors
aya Elshawash email orcid 1; Fatma Elgendyorcid 1; Olla Khalifa1; Shabaan Abd-Ellatif Hemeda2
1Genetics and Genetic engineering, Animal Wealth Development Department, Faculty of Veterinary Medicine, Benha University, Egypt
2Genetics and Genetic engineering, Animal Wealth Development Department, Faculty of Veterinary Medicine, Alexandria University, Alexandria
Abstract
This research was undertaken in order to determine the impact of nutritional vitamin E on genetic expression of Interferon-gamma (IFN-γ) and Interleukin-1β (IL-1β) as pro-inflammatory and Interleukin-4 (IL-4) and Interleukin-10 (IL-10) as anti-inflammatory cytokines in spleen and liver, heamagglutination inhibition antibody titers (HI titers) against Newcastle Disease Virus (NDV), total protein, albumin, globulin and growth efficiency of broiler chickens. Seventy two one-day-old Cobb broiler chicks had been allocated randomly into two groups. Each group has 3 replicates, each with 12 chicks. The first group was given basal diet. The second group was fed the basal diet with vitamin E (100 mg/kg diet). The obtained results revealed that dietary supplementation of vitamin E significantly (p < 0.05) increased growth efficiency, total protein, albumin, globulin and the antibody titers to NDV compared to the control group. Dietary supplementation of vitamin E significantly (P<0.05) decreased the expression of pro-inflammatory (IL-1β, IFN-γ) and anti-inflammatory (IL-4 and IL-10) cytokines in spleen and liver. In Conclusions: vitamin E supplementation (100 mg/kg diet) can enhance growth efficiency, serum total protein, albumin, globulin and humoral immunity, down-regulate pro-inflammatory and anti-inflammatory cytokines gene expression in broiler chickens.
Keywords
Broilers; Vitamin E; Cytokines; Humoral immunity; Growth efficiency
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