Significance of MUC4 in epithelioid mesothelioma of the pleura, adenocarcinoma & squamous cell carcinoma of the lung (Immunohistochemical Study)
Elsayed, E., Ahmed, H., Abdelaziz, T., Youssef, S. (2022). Significance of MUC4 in epithelioid mesothelioma of the pleura, adenocarcinoma & squamous cell carcinoma of the lung (Immunohistochemical Study). EKB Journal Management System, 39(Special issue (Academic)), 63-77. doi: 10.21608/bmfj.2021.46914.1330
Enas Ibrahim Elsayed; Heba Hassan Ahmed; Taghreed Abdelsamee Abdelaziz; Samia Ahmed Youssef. "Significance of MUC4 in epithelioid mesothelioma of the pleura, adenocarcinoma & squamous cell carcinoma of the lung (Immunohistochemical Study)". EKB Journal Management System, 39, Special issue (Academic), 2022, 63-77. doi: 10.21608/bmfj.2021.46914.1330
Elsayed, E., Ahmed, H., Abdelaziz, T., Youssef, S. (2022). 'Significance of MUC4 in epithelioid mesothelioma of the pleura, adenocarcinoma & squamous cell carcinoma of the lung (Immunohistochemical Study)', EKB Journal Management System, 39(Special issue (Academic)), pp. 63-77. doi: 10.21608/bmfj.2021.46914.1330
Elsayed, E., Ahmed, H., Abdelaziz, T., Youssef, S. Significance of MUC4 in epithelioid mesothelioma of the pleura, adenocarcinoma & squamous cell carcinoma of the lung (Immunohistochemical Study). EKB Journal Management System, 2022; 39(Special issue (Academic)): 63-77. doi: 10.21608/bmfj.2021.46914.1330

Significance of MUC4 in epithelioid mesothelioma of the pleura, adenocarcinoma & squamous cell carcinoma of the lung (Immunohistochemical Study)

Benha Medical Journal
Article 182, Volume 39, Special issue (Academic), September and October 2022, Page 63-77  XML PDF (1.14 MB)
Document Type: Original Article
DOI: 10.21608/bmfj.2021.46914.1330
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Authors
Enas Ibrahim Elsayed1; Heba Hassan Ahmed email 2; Taghreed Abdelsamee Abdelaziz3; Samia Ahmed Youssef4
1pathology,faculty of medicine, benha university, benha, Egypt
2pathology, faculty of medicine, benha university,benha, Egypt
3pathology, faculty of medicine, benha university, benha, Egypt
4Pathology Department-Faculty of Medicine-Benha University
Abstract
Background: Lung cancer is the second most common cancer, and the leading cause of cancer mortality. Malignant pleural mesothelioma is a highly aggressive malignant neoplasm, and epithelioid mesothelioma is the commonest histological subtype. MUC4 is a high-molecular weight glycoprotein that encoded by MUC4 gene.
Aim: The aim of this study was to evaluate MUC4 expression in LAC, LSqCC, and PEM.
Materials and Methods: This retrospective study was done upon 70 different lung and pleural lesions designated as; 30 cases of LAC, 20 cases of LSqCC and 20 cases of PEM. MUC4 immunostaining was done and assessed for each case.
Results: There is high significant statistical correlation between MUC4 expression with LAC, LSqCC, and PEM cases (P value=0.0001). 90% and 95% of LAC and LSqCC respectively are positive. All PEM cases are negative. The sensitivity and specificity of MUC4 in differentiating PEM from lung cancer including LAC and LSqCC are 92% and 100% respectively. Significant statistical correlation is found between MUC4 and histological subtype (P value > 0.05), grade (P < 0.01), and TNM stage (P < 0.05) of LAC. Significant statistical inverse correlation is found between MUC4 expression and grade of LSqCC (P value> 0.05).
Conclusions: MUC4 IHC can differentiate PEM from LAC and LSqCC. MUC4 expression increases with aggressive LAC, and increases with well-differentiated LSqCC.
Keyword: lung cancer, pleural mesothelioma, MUC4.
Abbreviations: Lung adenocarcinoma (LAC), Lung squamous cell carcinoma (LSqCC), Pleural epithelioid mesothelioma (PEM).
Keywords
lung cancer; pleural mesothelioma; MUC4
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