Titanium-Induced Histological and Immunohistochemical Alterations in Liver, Spleen, Lung and Kidney in Male Albino Rats
El Kelany, R., Moustafa, K., El Mehy, G. (2013). Titanium-Induced Histological and Immunohistochemical Alterations in Liver, Spleen, Lung and Kidney in Male Albino Rats. EKB Journal Management System, 20(1), 146-157. doi: 10.21608/ajfm.2013.19400
Rabab El Kelany; Khaled Moustafa; Ghada El Mehy. "Titanium-Induced Histological and Immunohistochemical Alterations in Liver, Spleen, Lung and Kidney in Male Albino Rats". EKB Journal Management System, 20, 1, 2013, 146-157. doi: 10.21608/ajfm.2013.19400
El Kelany, R., Moustafa, K., El Mehy, G. (2013). 'Titanium-Induced Histological and Immunohistochemical Alterations in Liver, Spleen, Lung and Kidney in Male Albino Rats', EKB Journal Management System, 20(1), pp. 146-157. doi: 10.21608/ajfm.2013.19400
El Kelany, R., Moustafa, K., El Mehy, G. Titanium-Induced Histological and Immunohistochemical Alterations in Liver, Spleen, Lung and Kidney in Male Albino Rats. EKB Journal Management System, 2013; 20(1): 146-157. doi: 10.21608/ajfm.2013.19400

Titanium-Induced Histological and Immunohistochemical Alterations in Liver, Spleen, Lung and Kidney in Male Albino Rats

Ain Shams Journal of Forensic Medicine and Clinical Toxicology
Article 14, Volume 20, Issue 1, January 2013, Page 146-157  XML PDF (5.43 MB)
Document Type: Original Article
DOI: 10.21608/ajfm.2013.19400
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Authors
Rabab El Kelany1; Khaled Moustafa2; Ghada El Mehy3
1Forensic Medicine & Clinical Toxicology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
2Histology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.
3Orthodontics Department, Faculty of Dentistry, Tanta University, Tanta, Egypt
Abstract
Different metals are increasingly used to manufacture implants, especially in the field of dentistry. Metallic implants of titanium are used therapeutically in biomedicine because of their high corrosion resistance and excellent biocompatibility when compared to more conventional stainless steels and cobalt-based alloys. However, no metal or alloy is completely inert. Thus the aim of the present study was to determine the histopathological and immuno-histochemical effects in some target organs of adult male albino rats induced by titanium exposure. This work was carried out on two groups: control group which included 10 rats and treated group which included 20 rats that received intraperitoneal injection of suspension of titanium dioxide (TiO2) in a dose of 150 mg/kg body weight (BW) per day for 45 days. Samples of liver, spleen, kidney, and lung were processed for histological examination. Cryostat sections of spleen samples from each group were stained with common lymphocytic antigen (CLA) for lymphocyte detection. Results revealed histopathological changes in the liver, spleen, lung and kidney of the treated group. The CLA staining of the spleen in the treated group revealed toxic alteration within the spleen, indicating that the immune system may be affected and so interfering in the body defense mechanism.
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