Relation between Theophylline Serum Level with ECG Changes and Poison Severity Score (PSS) Among Some Theophylline Intoxicated Patients in Menofia Poison Control Center (MPCC) A Prospective Study
Amin, S., El Seidy, A., Hammad, S., Habib, N. (2013). Relation between Theophylline Serum Level with ECG Changes and Poison Severity Score (PSS) Among Some Theophylline Intoxicated Patients in Menofia Poison Control Center (MPCC) A Prospective Study. EKB Journal Management System, 20(1), 170-179. doi: 10.21608/ajfm.2013.19404
Safaa Amin; Amira El Seidy; Samy Hammad; Nagwa Habib. "Relation between Theophylline Serum Level with ECG Changes and Poison Severity Score (PSS) Among Some Theophylline Intoxicated Patients in Menofia Poison Control Center (MPCC) A Prospective Study". EKB Journal Management System, 20, 1, 2013, 170-179. doi: 10.21608/ajfm.2013.19404
Amin, S., El Seidy, A., Hammad, S., Habib, N. (2013). 'Relation between Theophylline Serum Level with ECG Changes and Poison Severity Score (PSS) Among Some Theophylline Intoxicated Patients in Menofia Poison Control Center (MPCC) A Prospective Study', EKB Journal Management System, 20(1), pp. 170-179. doi: 10.21608/ajfm.2013.19404
Amin, S., El Seidy, A., Hammad, S., Habib, N. Relation between Theophylline Serum Level with ECG Changes and Poison Severity Score (PSS) Among Some Theophylline Intoxicated Patients in Menofia Poison Control Center (MPCC) A Prospective Study. EKB Journal Management System, 2013; 20(1): 170-179. doi: 10.21608/ajfm.2013.19404

Relation between Theophylline Serum Level with ECG Changes and Poison Severity Score (PSS) Among Some Theophylline Intoxicated Patients in Menofia Poison Control Center (MPCC) A Prospective Study

Ain Shams Journal of Forensic Medicine and Clinical Toxicology
Article 16, Volume 20, Issue 1, January 2013, Page 170-179  XML PDF (3.14 MB)
Document Type: Original Article
DOI: 10.21608/ajfm.2013.19404
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Authors
Safaa Amin; Amira El Seidy; Samy Hammad; Nagwa Habib
Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Menoufia University, Shibin Al Kawm, Egypt.
Abstract
There are numerous toxins and drugs that can cause, in overdose, ECG changes, even in patients without history of cardiac pathology. Theophylline intoxication results in substantial morbidity and mortality, particularly in those with chronic overmedication. The aim of this work was to study ECG changes in cases of poisoning by theophylline overdose that were admitted to MPCC over 2011 and the relation between ECG changes, theophylline blood level and poison severity score. In this study, theophylline overdose patients admitted to MPCC in the period from 1st of January 2011 to 31st of December 2011 were included. The total patients' number was 44 patients. Most cases of the study were females (77.2%) in the age group of (20-<40) years (40.9%), mainly from rural side (65.9%). Regarding relation between theophylline serum level and clinical manifestations, a significant relation was found between serum level and each of vomiting and dizziness, where both were noticed with majority of cases of minimal and moderate toxicity serum level. Regarding poison severity score, exactly one half of moderate and severe cases had minimal toxicity serum level, and the other half had moderate toxicity level. A significant negative correlation between theophylline serum level and PCO2 was found. There was a non significant negative correlation between theophylline serum level and each of Na and K blood level. Concerning ECG changes, a significant relation was found between theophylline serum level and each of sinus tachycardia and second degree heart block.
Keywords
Theophylline; poison; eCG; Poison Severity Score; Chemiluminescent immunoassay
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