Mitoxantrone in Synergism with Gold Hexagonal Nanoparticles and Gamma Radiation for Effective Treatment of MCF7 Cells | ||||
| Egyptian Journal of Chemistry | ||||
| Article 61, Volume 65, Issue 3, March 2022, Page 647-655 PDF (552.96 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2021.86310.4185 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
wael darwish   1; Rowad A Lafta2; Medhat Wahba Shafaa3; Mohamed S El-Nagdy4
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| 1national research centre | ||||
| 2Physics Department, Faculty of Science, Helwan University, Cairo, Egypt. | ||||
| 3Physics Dept., Medical Biophysics Division Faculty of Science Helwan University | ||||
| 4Physics Department, Faculty of Science, Helwan University, Cairo, Egypt | ||||
| Abstract | ||||
| Biocompatible cross-linked chitosan nanoparticles comprising the cancer chemotherapeutic drug (mitoxantrone, MX) and the novel radiosensitizer hexagonal gold nanoparticles (HG) were prepared and characterized. The prepared nanoparticles were applied, in synergism with external γ-radiation, as dual (chemo-radio) model for treatment of human breast cancer cell (MCF-7). In vitro studies revealed that HG significantly enhances the response of MCF-7 to low and moderate doses of γ-radiation (2 and 4 Gy). Cell viability assay demonstrated the synergistic anticancer actions of mitoxantrone chemotherapy and gold-sensitized γ-radiation therapy. The prepared combinatorial model is potential for efficient and safer treatment of MCF7 cancer cells. | ||||
| Keywords | ||||
| Hexagonal gold; chitosan nanoparticles; mitoxantrone; MCF-7; radiotherapy | ||||
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