Effect of Stevia rebaudiana and exercise on fatty liver in type 2 diabetic rats | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Article 1, Volume 41, Issue 4, October 2021, Page 428-440 PDF (728.14 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2021.48134.1083 | ||||
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| Authors | ||||
Reem Mohie ElDin Emam   1; abdelaziz hussein 2; Asaad Elmileegy3; Fayza R. El-Menabawy3; Gad El Mawla A. Gad4
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| 1Department of physiology, faculty of medicine, Mansoura university | ||||
| 2faculty of medicine, mansoura university | ||||
| 3Department of Medical Physiology, Faculty of Medicine, Mansoura University, Egypt | ||||
| 4Department of Medical Physiology, Faculty of Medicine, Mansoura University, Egypt. | ||||
| Abstract | ||||
| Introduction: Nonalcoholic fatty liver disease (NAFLD) is a prevalent chronic liver disease, which threatens the health of both adults and children. It is strongly associated with type 2 diabetes mellitus, obesity and insulin resistance. In the present study, we evaluate the effect of Stevia rebaudiana and exercise on fatty liver in T2DM. Methods: Thirty two male Sprague Dawely rats were divided into normal control, diabetic, Stevia treated diabetic, and exercise treated diabetic rats. Biochemical parameters, oxidative stress markers, and histopathological examination for liver tissue were done. Results: in diabetic group, blood glucose level, HOMA index, cholesterol level, triglycerides level, bilirubin level, liver enzymes (ALT& AST), and MDA were significantly increased. While insulin level, GSH, and CAT activity were significantly decreased when compared to normal control group. Biochemical parameters and Oxidative stress markers were improved in the treated groups, the improvement was more significant in exercise treated group than Stevia treated group. Histopathological examination confirmed our results. Conclusion: Stevia rebaudiana and exercise could protect against liver injury induced by T2DM, as they improve glycemic state, liver enzymes, and oxidative stress markers. Key words: NAFLD, T2DM, Stevia, Exercise. | ||||
| Keywords | ||||
| NAFLD; T2DM; Stevia; Exercise | ||||
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