P- coumaric acid prevents fructose induced dyslipedemia and hypertension
Mohammed, M., Khowailed, A., Abdelhakam, A. (2021). P- coumaric acid prevents fructose induced dyslipedemia and hypertension. EKB Journal Management System, 41(4), 500-508. doi: 10.21608/besps.2021.57781.1092
Marwa Mohammed; Akef Khowailed; Ahmed Abdelhakam. "P- coumaric acid prevents fructose induced dyslipedemia and hypertension". EKB Journal Management System, 41, 4, 2021, 500-508. doi: 10.21608/besps.2021.57781.1092
Mohammed, M., Khowailed, A., Abdelhakam, A. (2021). 'P- coumaric acid prevents fructose induced dyslipedemia and hypertension', EKB Journal Management System, 41(4), pp. 500-508. doi: 10.21608/besps.2021.57781.1092
Mohammed, M., Khowailed, A., Abdelhakam, A. P- coumaric acid prevents fructose induced dyslipedemia and hypertension. EKB Journal Management System, 2021; 41(4): 500-508. doi: 10.21608/besps.2021.57781.1092

P- coumaric acid prevents fructose induced dyslipedemia and hypertension

Bulletin of Egyptian Society for Physiological Sciences
Article 5, Volume 41, Issue 4, October 2021, Page 500-508  XML PDF (371.47 K)
Document Type: Original Article
DOI: 10.21608/besps.2021.57781.1092
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Authors
Marwa Mohammed email 1; Akef Khowailed2; Ahmed Abdelhakam3
1Department of Physiology, Faculty of Medicine, Beni-Suef University, Egypt
2Department of physiology, Faculty of Medicine, Cairo University, Egypt
3Department of physiology, Beni-Suef University, Egypt
Abstract
In recent decades, rates of insulin resistance and hypertension
increase dramatically due to many factors. One of them is excessive fructose consumption. P-coumaric acid has potent antioxidant and anti hyperglycemic properties. Aim of the work: In this study, we examined the ability of p-coumaric acid to prevent high fructose induced hypertension and the possible underlying mechanisms. Material and methods: 24 adult male albino rats were divided randomly into 3 groups; control group, fructose group received fructose 60% dissolved in water for 5 weeks and P-coumaric acid + fructose group received P-coumaric acid dissolved in carboxy methyl cellulose 100ml/kg/day orally for 2 weeks then fructose 60% dissolved in water for 5 weeks. For each rat, blood pressure was measured and a blood sample was taken by retro orbital method under ether anesthesia for measurement of plasma level of glucose,triglycerides (TG) and high density lipoprotein (HDL), then triglycerides glucose (TYG) index and atherogenic index were calculated. Results: Fructose group showed significant increases of blood pressure, plasma glucose, TG, TYG index and atherogenic index while showed a significant decrease of plasma HDL when compared to control group (p < 0.01). P-coumaric acid reversed these results. Conclusion: P-coumaric acid protects against hypertension induced by high fructose diet.
Keywords
P-coumaric acid; Fructose induced hypertension; insulin resistance
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