Impact of electronic cigarette vaping on the cytoarchitecture of the tongue in the adult male albino rat
mandour, D., Saber, S., Soliman, R., Abdelfattah, M. (2022). Impact of electronic cigarette vaping on the cytoarchitecture of the tongue in the adult male albino rat. EKB Journal Management System, 28(6), 1346-1354. doi: 10.21608/zumj.2021.88065.2301
Dalia A. mandour; Sara Mohamed Saber; Rania Hassan Mohamed Soliman; Marwa Tharwat Abdelfattah. "Impact of electronic cigarette vaping on the cytoarchitecture of the tongue in the adult male albino rat". EKB Journal Management System, 28, 6, 2022, 1346-1354. doi: 10.21608/zumj.2021.88065.2301
mandour, D., Saber, S., Soliman, R., Abdelfattah, M. (2022). 'Impact of electronic cigarette vaping on the cytoarchitecture of the tongue in the adult male albino rat', EKB Journal Management System, 28(6), pp. 1346-1354. doi: 10.21608/zumj.2021.88065.2301
mandour, D., Saber, S., Soliman, R., Abdelfattah, M. Impact of electronic cigarette vaping on the cytoarchitecture of the tongue in the adult male albino rat. EKB Journal Management System, 2022; 28(6): 1346-1354. doi: 10.21608/zumj.2021.88065.2301

Impact of electronic cigarette vaping on the cytoarchitecture of the tongue in the adult male albino rat

Zagazig University Medical Journal
Article 21, Volume 28, Issue 6, November 2022, Page 1346-1354  XML PDF (570.98 K)
Document Type: Original Article
DOI: 10.21608/zumj.2021.88065.2301
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Authors
Dalia A. mandourorcid 1; Sara Mohamed Saber email 2; Rania Hassan Mohamed Soliman2; Marwa Tharwat Abdelfattahorcid 3
1Department of Human Anatomy and Embryology, Faculty of Medicine, Zagazig University, Egypt
2Department of Human Anatomy and Embryology, Faculty of Medicine, Zagazig University, Egypt
3Department of Human Anatomy and Embryology, Faculty of Medicine, Zagazig university, Egypt
Abstract
Background: Electronic cigarettes (E-cigs) are marketed as an alternative and replacement domain to the traditional cigarette smoking in many societies for the rescue of smoking cessation. Nevertheless, the vape of E-cigs produce different harmful chemical compounds and carcinogens. Aim: To clarify the histopathological changes that may take place in rat’s tongue after exposure to E-cigs and to assess the possible amelioration of such changes after giving up vaping. Methods: Thirty adult male albino rats were divided into three equal groups. Control group: exposed to fresh air for 4weeks. Exposed group: exposed to smoke vapor of 1ml burnt E-liquid for 1 hour, 5 consecutive days/ week for 4 weeks. Withdrawal group: exposed to the same dose and duration of smoke vapor like group 2 then left without exposure for another 4 weeks. By the end of the experiment, animals were weighted and the tongue was excised and processed for hematoxylin& eosin and Alcian blue/periodic acid Schiff’s staining and for proliferating cell nuclear antigen (PCNA) immunohistochemical study. Also, serum malondialdehyde and superoxide dismutase activity were determined. Results: E-cigs exposure hampered the cytoarchitecture of the tongue with loss of some papillae and hyperkeratosis of the others along with increased PCNA immunoreactivity and its area percentage. Also, E-cigs exposure led to redox imbalance. Obviously, stoppage of E-cigs exposure resulted in partial amelioration of histological and biochemical changes. Conclusion: E-cigs vaping produced proliferative changes that impose a metaplasia in the tongue and their withdrawal revealed some degree of improvement.
Keywords
Keywords: Electronic cigarettes; Vaping; Rat's Tongue; Withdrawal; Electronic cigarettes liquid
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