New and Facile Synthesis of Pyrimidine, Coumarine, Pyrimido[1,6-a]Pyrimidine, 1,2,4-Triazine and Pyrimido[4,5-c] Pyridazine Derivatives | ||||
Scientific Journal for Damietta Faculty of Science | ||||
Article 3, Volume 2, Issue 1, 2013, Page 15-22 PDF (378.41 K) | ||||
Document Type: Original articles | ||||
DOI: 10.21608/sjdfs.2013.194282 | ||||
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Authors | ||||
F. M.A El-Taweel 1; S. B.A. Said2; S. M.A. Ramadan2; A. A. Elagamey2 | ||||
1Department of Chemistry, Faculty of Science, New Damietta City, Damietta University, Egypt | ||||
2Chemistry Department, Faculty of Science, Damietta University | ||||
Abstract | ||||
Condensation of cyanoacetylurea 1 with aromatic aldehydes gave the arylidenes 2a-d. Compound 2a cyclised to the pyrimidone 4 by boiling in DMF/Et3N. Compound 1 condensed with 2,4-dihydroybenzaldehyde to give the arylidene 6 .Cyclisation of 6 yield the coumarine 7.Coupling of 1 with aryl diazonium salts gave aryl hydrazones 9a,b. Compound 9a cyclised to 10 . Compound 10 reacted with malononitrile to give pyrimido [1,6-a] pyrimidine 11. Reaction of 9b with triethyl orthoformate and ethyl chloroformate afforded 1,2,4-triazines 13 and 15 respectively. Condensation of 1 with arylhydrazone 16 yielded pyrimido[4,5-c] pyridazine 19. | ||||
Keywords | ||||
Cyanoacetylurea; pyrimidine; coumarine; 1; 2; 4-triazine | ||||
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