CORRELATION BETWEEN URINARY BISPHENOL A LEVELS WITH INSULIN RESISTANCE AND DIABETES COMPLICATIONS IN CHILDREN WITH TYPE 1 DIABETES MELLITUS | ||||
| Al-Azhar Journal of Pediatrics | ||||
| Article 9, Volume 24, Issue 2, April 2021, Page 2098-2113 PDF (183.59 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/azjp.2021.194418 | ||||
 View on SCiNiTO | ||||
| Abstract | ||||
| Introduction: Bisphenol A (BPA) is ubiquitous in our environment, as evidenced by the fact that over 90 % of individuals have detectable levels of BPA present in their urine, which is the primary route of excretion in humans. BPA has been found in neonates, children and adults, and can be measured in a range of body fluids and tissues, including urine, blood, saliva, placental tissue, adipose tissue and breast milk (Vandenberg et al., 2010). Objectives: The aim of this study was to assess the association between BPA exposures by measuring urinary levels of BPA, insulin resistance using estimated glucose disposal rate, glycemic control using mean value of HbA1C and diabetes complications in type 1 diabetic children. Subjects and Methods: This is a descriptive cross-sectional study that was carried out on 100 children with type 1 DM. they are selected by simple random method from the attendants of Pediatric Endocrinology Outpatient Clinic, Abo Elrish Pediatric Hospital, Cairo University, Egypt and Pediatric Endocrinology Outpatient Clinic of EL-Hussein University Hospital, Al Azhar University during the period from April 2019 to March 2021. Results: The mean age of the studied diabetic children was 12.9 ± 2.24 years. And the onset of diagnosis of diabetes was 5.33 ± 2.25 years old. The mean duration of diabetes was 7.59 ± 1.9 years. There were significantly higher level of HBA1c, serum Cholesterol, and serum Triglyceride, among bisphenol positive groups compared to bisphenol negative group, (P<0.05).Regarding ROC curve for glucose disposal rate which shows insulin resistance it showed that the best cutoff of glucose disposal rate at 11.72 (sensitivity 75% and specificity 70.8, P<0.05). Conclusion: Significant association between BPA exposures, insulin resistance and diabetes complications in type 1 diabetic children. | ||||
|
Statistics Article View: 150 PDF Download: 207 |
||||
