Effect of Adding Metformin to Insulin Therapy in Pregnant Women with Uncontrolled Type I Diabetes as Regard Pregnancy Outcome
Abdullah, A., Gabr, A., Hamed, D., Eweis, M. (2021). Effect of Adding Metformin to Insulin Therapy in Pregnant Women with Uncontrolled Type I Diabetes as Regard Pregnancy Outcome. EKB Journal Management System, 11(3), 240-247. doi: 10.21608/ebwhj.2021.82768.1144
Amal Abdullah; Amir Gabr; Doaa Hamed; Mohamed Eweis. "Effect of Adding Metformin to Insulin Therapy in Pregnant Women with Uncontrolled Type I Diabetes as Regard Pregnancy Outcome". EKB Journal Management System, 11, 3, 2021, 240-247. doi: 10.21608/ebwhj.2021.82768.1144
Abdullah, A., Gabr, A., Hamed, D., Eweis, M. (2021). 'Effect of Adding Metformin to Insulin Therapy in Pregnant Women with Uncontrolled Type I Diabetes as Regard Pregnancy Outcome', EKB Journal Management System, 11(3), pp. 240-247. doi: 10.21608/ebwhj.2021.82768.1144
Abdullah, A., Gabr, A., Hamed, D., Eweis, M. Effect of Adding Metformin to Insulin Therapy in Pregnant Women with Uncontrolled Type I Diabetes as Regard Pregnancy Outcome. EKB Journal Management System, 2021; 11(3): 240-247. doi: 10.21608/ebwhj.2021.82768.1144

Effect of Adding Metformin to Insulin Therapy in Pregnant Women with Uncontrolled Type I Diabetes as Regard Pregnancy Outcome

Evidence Based Women's Health Journal
Article 6, Volume 11, Issue 3, August 2021, Page 240-247  XML PDF (1.22 MB)
Document Type: Original Article
DOI: 10.21608/ebwhj.2021.82768.1144
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Authors
Amal Abdullah1; Amir Gabr2; Doaa Hamed3; Mohamed Eweis email 4
1Department of Obstetrics and Gynecology, Faculty of Medicine, Beni-Suef University Hospita
2Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo university
3Department of Obstetrics and Gynecology, Faculty of Medicine, Beni-Suef University Hospital
4Department of Obstetrics and Gynecology, Faculty of Medicine, Beni-Suef University Hospital,
Abstract
Aim: This study aimed to examine if addition of metformin to insulin is an effective alternative to insulin alone for women with type I Diabetes Mellitus to lower insulin dose, hospital stay, maternal and neonatal complications, particularly in a resource-poor setting.
Materials and Methods: Our randomized controlled trial included eighty patients, who were recruited into two equal groups; group A treated with metformin and insulin and group B treated with insulin alone, in Cairo and Beni-suef University Hospitals.
Results: We found that metformin plus insulin group (Group A) showed significant outcomes regarding shorted hospital stay, lower insulin dose and lower maternal weight gain (p values 0.04, 0.02, 0.03, respectively). Most of maternal and neonatal complications were non-significantly lower in group A.
Conclusion: Oral metformin therapy is an effective and safe additional treatment option for women with type I diabetes during pregnancy to lower the insulin requirements, hospital stay and most maternal-fetal complications in settings with limited economic resources.
Keywords
GDM; maternal complications of type I diabetes mellitus; metformin in pregnancy; neonatal complications; type I diabetes mellitus
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