Serum Kisspeptin-1 at time of Pregnancy Diagnosis is superior to serum βhCG for prediction of Early Pregnancy Loss | ||||
| The Egyptian Journal of Fertility of Sterility | ||||
| Article 7, Volume 25, Issue 3, September 2021, Page 65-74 PDF (2.28 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/egyfs.2021.195180 | ||||
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| Author | ||||
| Basma E. Sakr, Amira MN Abdelrahman, | ||||
| Departments of Obstetrics & Gynecology, and Clinical & Chemical Pathology*, Faculty of Medicine, Benha University | ||||
| Abstract | ||||
| Objectives: Estimation of serum Kisspeptin-1 (Kiss-1) and beta human chorionic gonadotropin (βhCG) levels at time of pregnancy diagnosis (Booking time) and at the 12th gestational week; S1 and S2 samples, in trial to evaluate the predictability of these levels for the possibility of early pregnancy loss (EPL). Patients & Methods: 283 women gave S2 samples, 76 women (26.9%) developed EPL (EPL group) and 207 women had viable fetus (Control group). Blood samples were obtained for ELISA estimation of serum Kiss-1 and βhCG. The study outcome was the predictability of S1 levels of both parameters for the possibility of oncoming pregnancy loss. Results: S1 sample βhCG levels showed non-significant differences between both groups, while serum Kiss-1 levels were significantly lower in EPL than in control women. Serum levels of both parameters in S2 sample were significantly lower in EPL than both control women and levels estimated in S1 samples of EPL women. Incidence of EPL was negatively correlated with S1 sample serum levels of both parameters. Regression analysis defined 6500 IU/L and 318 pmol/L as cutoff points for βhCG and Kiss-1 to predict 50% hazard for EPL. These cutoff points defined 158 and 181 true cases, respectively with significant difference in favor of Kiss-1 value. ROC curve analysis assured the sensitivity of lower S1 levels of both parameters for prediction of 50% hazard of EPL, but area difference under ROC was significant in favor of low serum Kiss-1 as a significant sensitive predictor for EPL. Conclusion: Estimation of serum kiss-1 at time of pregnancy diagnosis inversely correlates with incidence of EPL. Lower serum Kiss-1 levels had significantly higher predictability for EPL than βhCG. Lower serum Kiss-1 at the 12th GW or development of EPL assured the predictability of the result obtained at booking time and spared the need for sequential estimations. | ||||
| Keywords | ||||
| Keywords: Early pregnancy loss; Early prediction; Kisspeptin-1; βhCG | ||||
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