Role of GLUT-1 immunostaining in Diagnosis and prognosis of ovarian carcinoma. | ||||
| The Egyptian Journal of Fertility of Sterility | ||||
| Article 6, Volume 20, Issue 2, June 2016, Page 36-44 PDF (3.09 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/egyfs.2016.19533 | ||||
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| Authors | ||||
| Reham Nagib1; Reda Hemida2; Alaa Wageh2 | ||||
| 1Department of Pathology, Faculty of medicine, Mansoura University | ||||
| 2Department of Obstetrics and Gynecology, Faculty of medicine, Mansoura University. | ||||
| Abstract | ||||
| Background: close relationship between GLUT-1 expression and carcinogenesis, tumor development, and the unfavorable prognosis of several malignant tumors. Objective: To investigate the correlation of GLUT-1 immunostaining and clinic-pathologic features as well as prognosis of ovarian cancer patients. Materials and methods: Paraffin blocks of 76 cases were retrieved from archives of pathology department, Mansoura University. These included 57 cases with malignant ovarian tumors, 11 cases with benign ovarian tumors, and 8 cases with borderline ovarian tumors. The sectioned samples were stained with polyclonal antibody for GLUT-1. The degree of immunostaining were correlated with clinic-pathologic features as well as prognosis of ovarian cancer patients. Results: All benign tumors were negative for GLUT-1. Strong staining reaction for GLUT- I was significantly associated with the malignant phenotype (p=0.0001). Moreover, there was a statistically significant difference in staining intensity for GLUT-1 between borderline and malignant tumors (p=0.0028). There was a statistically significant correlation between high grade tumors and strong staining intensity (p=0.001). Correlation between staining reaction for GLUT-1 and developing metastases and/or recurrence was statistically significant (p=0.001). Conclusion: GLUT-1 is related to carcinogenesis of ovarian carcinomas. The statistically significant correlation between staining intensity for GLUT-1 and malignant phenotype can make it a marker for target therapy for ovarian cancer patients. In addition, GLUT-1 can be considered as predictor for metastases and recurrence in ovarian carcinoma that needs to be validated in future trials. | ||||
| Keywords | ||||
| Ovarian carcinoma; prognosis; GLUT-1; immunohistostaining | ||||
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