DNA Fragmentation in Spermatozoa due to Cadmium and Lead Intoxication among Some Egyptian Population
Attia, A., Zalata, A. (2012). DNA Fragmentation in Spermatozoa due to Cadmium and Lead Intoxication among Some Egyptian Population. EKB Journal Management System, 19(2), 104-112. doi: 10.21608/ajfm.2012.19542
Afaf Attia; Adel Zalata. "DNA Fragmentation in Spermatozoa due to Cadmium and Lead Intoxication among Some Egyptian Population". EKB Journal Management System, 19, 2, 2012, 104-112. doi: 10.21608/ajfm.2012.19542
Attia, A., Zalata, A. (2012). 'DNA Fragmentation in Spermatozoa due to Cadmium and Lead Intoxication among Some Egyptian Population', EKB Journal Management System, 19(2), pp. 104-112. doi: 10.21608/ajfm.2012.19542
Attia, A., Zalata, A. DNA Fragmentation in Spermatozoa due to Cadmium and Lead Intoxication among Some Egyptian Population. EKB Journal Management System, 2012; 19(2): 104-112. doi: 10.21608/ajfm.2012.19542

DNA Fragmentation in Spermatozoa due to Cadmium and Lead Intoxication among Some Egyptian Population

Ain Shams Journal of Forensic Medicine and Clinical Toxicology
Article 10, Volume 19, Issue 2, June 2012, Page 104-112  XML PDF (2.49 MB)
Document Type: Original Article
DOI: 10.21608/ajfm.2012.19542
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Authors
Afaf Attia1; Adel Zalata2
1Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt
2Biochemistry Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Abstract
The present study aimed to throw the light on cadmium and lead concentrations in seminal plasma among some Egyptian men with infertility history that are likely to be representative of those toxins among the Egyptian general population and to predict the most affected semen parameters by the above metals. In addition, the current study aims to explore the possible correlation of spermatozoa DNA damage with the cadmium and lead metals concentration. Ninety semen samples obtained from patients attending the andrology out-patient's clinic, Mansoura University Hospital. Studied groups include group of idiopathic infertile men (n=46) and group of fertile healthy men (n=44) who matched according to age and residence. Semen analysis results revealed highly statistical significant differences on comparing infertile to fertile groups. There was highly statistical significant increase in cadmium and lead seminal plasma levels on comparing infertile to fertile groups. DNA laddering test revealed 82.6% DNA damage in infertile group comparing to 11.4% in fertile group. The results revealed a positive correlation between both metals level and spermatozoa DNA damage percentage in infertile group. Linear regression analysis revealed that exposure to cadmium affected sperm motility then sperm function while, exposure to lead affected sperm motility then morphology. In conclusion, chronic low-level exposure to environmental toxicants such as cadmium and lead impair male reproductive ability.
Keywords
Male infertility; cadmium; Lead; Semen Analysis; DNA Laddering
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