Plasma Lactate as a Prognostic Biomarker in Acute Carbon Monoxide Toxicity
Abd El Razik, H., Abd El Wahab, M. (2012). Plasma Lactate as a Prognostic Biomarker in Acute Carbon Monoxide Toxicity. EKB Journal Management System, 19(2), 128-134. doi: 10.21608/ajfm.2012.19546
Hany Abd El Razik; Mahmoud Abd El Wahab. "Plasma Lactate as a Prognostic Biomarker in Acute Carbon Monoxide Toxicity". EKB Journal Management System, 19, 2, 2012, 128-134. doi: 10.21608/ajfm.2012.19546
Abd El Razik, H., Abd El Wahab, M. (2012). 'Plasma Lactate as a Prognostic Biomarker in Acute Carbon Monoxide Toxicity', EKB Journal Management System, 19(2), pp. 128-134. doi: 10.21608/ajfm.2012.19546
Abd El Razik, H., Abd El Wahab, M. Plasma Lactate as a Prognostic Biomarker in Acute Carbon Monoxide Toxicity. EKB Journal Management System, 2012; 19(2): 128-134. doi: 10.21608/ajfm.2012.19546

Plasma Lactate as a Prognostic Biomarker in Acute Carbon Monoxide Toxicity

Ain Shams Journal of Forensic Medicine and Clinical Toxicology
Article 13, Volume 19, Issue 2, June 2012, Page 128-134  XML PDF (2.15 MB)
Document Type: Original Article
DOI: 10.21608/ajfm.2012.19546
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Authors
Hany Abd El Razik1; Mahmoud Abd El Wahab2
1Fellow of Clinical Toxicology, Poison Control Center of Ain Shams University Hospitals, Cairo, Egypt.
2Fellow of Biochemistry, Poison Control Center of Ain Shams University Hospitals, Cairo, Egypt.
Abstract
Patients with acute carbon monoxide (CO) poisoning have been found to have a correlation between initial clinical severity on admission and blood lactate levels. Recently, it is suggested that the lactate level may be a useful prognostic factor in cases study. The purpose of this study was to assess whether plasma lactate levels can be used as a biomarker for the assessment of severity and outcome of acute carbon monoxide poisoning.  Selected Forty patientswhom presented to the Poison Control Centre (PCCA) of Ain Shams University Hospitals after acute CO poisoning, over 1 year, were included in this study. Based on clinical criteria, patients were classified into 3 groups (mild, moderate and severe). Blood pH, Carboxyhemoglobin (COHb), blood sugar (B.S), and lactate level were estimated in the blood of all patients. Our results revealed thatthe blood lactate level was significantly increased in all poisoned patients and the dead patients showed significant increase of blood lactate at time of admission when compared with the survived patients. The correlation study revealed positive correlation between plasma lactate level with B.S levels, COHb levels and the delay time and negative correlation with blood pH. It is concluded that the initial blood lactate may correlate with the patient outcomes and prove to be a useful prognostic factor in acute CO poisoning. Thus lactate level is recommended to be considered in cases of acute CO poisoning.
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