CLINICAL SIGNIFICANCE OF CIRCULATING CIRCADIAN PROTEINS BMAL1 AND PERIOD2 IN PATIENTS WITH HEPATITIS C VIRUS-RELATED LIVER | ||||
| ALEXMED ePosters | ||||
| Article 221, Volume 3, Issue 4, December 2021, Page 52-53 | ||||
| Document Type: Preliminary preprint short reports of original research | ||||
| DOI: 10.21608/alexpo.2021.96673.1274 | ||||
 View on SCiNiTO | ||||
| Author | ||||
Hadeer Khamis Bassiouni 
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| Department of internal medicine faculty of medicine | ||||
| Abstract | ||||
| INTRODUCTION Hepatitis C virus (HCV) infection is a major cause of chronic liver disease worldwide. The circadian clock (CC) is an endogenous timekeeping system that synchronizes 24-hr oscillations of behavioral and biological processes. The CC machinery forms a feedback timing circuit and is composed of a series of genes. Brain and muscle Arnt-like protein 1 (BMAL1) and Period 2 (PER2) genes are crucial components of the CC. Disruption of the circadian rhythms is linked to a variety of diseases including viral infections, liver diseases, metabolic derangements, and cancer. AIM OF THE WORK The present study was conducted to assess the clinical significance of circulating circadian proteins BMAL1 and PER2, positive and negative regulators of the CC, in patients with HCV-related liver disease. SUBJECTS 60 patients with chronic HCV infection {20 patients with chronic hepatitis C (CHC), 20 cirrhotic patients without hepatocellular carcinoma (HCC), 20 cirrhotic patients with HCC] and 20 healthy controls. Exclusion criteria: other causes of chronic liver disease; infections; inflammatory disorders; or malignancy; cardiac, respiratory or renal disease; previous antiviral or HCC treatment. | ||||
| Keywords | ||||
| VIRUS-RELATED; LIVER DISEASE; CIRCULATING CIRCADIAN | ||||
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