Some 3,4,5-Trisubstituted-1,2,4-triazole Synthesis, Antimicrobial Activity, and Molecular Docking Studies

Ahmed, Ahmed; Majeed, Ismaeel Y.; Asaad, Noora; Ahmed, Riyadh Mahmood; Kamil, Ghada M.; Abdul Rahman, Sarah

doi:10.21608/ejchem.2021.93025.4397

	Some 3,4,5-Trisubstituted-1,2,4-triazole Synthesis, Antimicrobial Activity, and Molecular Docking Studies
Egyptian Journal of Chemistry
Article 37, Volume 65, Issue 3, March 2022, Page 395-401 PDF (870.08 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2021.93025.4397
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Authors
Ahmed Ahmed¹; Ismaeel Y. Majeed ²; Noora Asaad¹; Riyadh Mahmood Ahmed³; Ghada M. Kamil⁴; Sarah Abdul Rahman³
¹Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, Iraq.
²Department of Chemistry, College of Education for Pure Science Ibn-Al-Haitham, University of Baghdad, Iraq
³Department of Chemistry, College of Education for Pure Science Ibn-Al-Haitham, University of Baghdad, Iraq.
⁴Department Of Applied sciences, Branch of Applied Chemistry, University Of Technology, Baghdad, Iraq.
Abstract
Methyl 4-aminopicolinate 1 interacted with hydrazine hydrate and subsequently with carbon disulfide to produce a triazole thiol derivative, which then reacted with different aldehydes to produce the appropriate Schiff base products. 4a-c. The reaction of Schiff base products 4a-c with benzoyl chloride resulted in the formation of trisubstituted triazoles 5a-c. The spectroscopic studies of the produced chemicals helped to clarify their structures. The antibacterial activity of the produced compounds against various bacterial and fungal strains was tested. Molecular docking studies of newly synthesized 1,2,4-triazoles were also conducted.
Keywords
Triazole; Schiff base; Molecular Docking; Antimicrobial activity


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