CD44 and p53 co-expression in high grade, muscle invasive bladder urothelial carcinoma with and without schistosomiasis
Sharaf El Deen, R., Sayed, O., Moustafa, W. (2021). CD44 and p53 co-expression in high grade, muscle invasive bladder urothelial carcinoma with and without schistosomiasis. EKB Journal Management System, 5(3), 69-75. doi: 10.21608/jcbr.2021.39890.1064
Rehab Sharaf El Deen; Osama Sayed; Wesam Moustafa. "CD44 and p53 co-expression in high grade, muscle invasive bladder urothelial carcinoma with and without schistosomiasis". EKB Journal Management System, 5, 3, 2021, 69-75. doi: 10.21608/jcbr.2021.39890.1064
Sharaf El Deen, R., Sayed, O., Moustafa, W. (2021). 'CD44 and p53 co-expression in high grade, muscle invasive bladder urothelial carcinoma with and without schistosomiasis', EKB Journal Management System, 5(3), pp. 69-75. doi: 10.21608/jcbr.2021.39890.1064
Sharaf El Deen, R., Sayed, O., Moustafa, W. CD44 and p53 co-expression in high grade, muscle invasive bladder urothelial carcinoma with and without schistosomiasis. EKB Journal Management System, 2021; 5(3): 69-75. doi: 10.21608/jcbr.2021.39890.1064

CD44 and p53 co-expression in high grade, muscle invasive bladder urothelial carcinoma with and without schistosomiasis

Egyptian Journal of Cancer and Biomedical Research
Article 7, Volume 5, Issue 3, September 2021, Page 69-75  XML PDF (4.64 MB)
Document Type: Original Article
DOI: 10.21608/jcbr.2021.39890.1064
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Authors
Rehab Sharaf El Deen email 1; Osama Sayed2; Wesam Moustafa3
1Pathology Department, Faculty of Medicine, Beni Suef University, Beni Suef, Egypt
2Urology Department, Faculty of Medicine, Beni Suef University, Beni Suef, Egypt
31Pathology Department, Faculty of Medicine, Beni Suef University, Beni Suef, Egypt
Abstract
Background & Objectives: In Egypt, most patients diagnosed as urothelial carcinoma (UC) have high grade and muscle-invasive tumors that are commonly associated with schistosomal cystitis. CD44 and p53 may represent potential targets for anticancer treatment. We aimed to assess the expression of CD44 & p53 and to determine their association in high grade, muscle-invasive tumors. Materials and Methods: Thirty four cystectomy cases with high-grade muscle-invasive UC were collected. Sections were stained for CD44 and p53 taking 10% and 20% positivity as cutoff values, respectively. Results: Median age was 60.5 years. Male/female ratio was 4:1.Fourteen cases were T2, 12 were T3, and 8 were T4. Nodal metastasis was evident in 8 cases. Conventional histology was seen in 38%, followed by squamous differentiation in 24%. Twenty patients had bilharzial cystitis. CD44 was positive in 8.8% of cases whereas p53 immunopositivity was noted in 76.5%. CD44 and p53 expression had no statistical association with stage (p < /em>=0.52 and 0.97) or bilharzial infestation (p=0.34 and 0.16). There was no significant association between CD44 expression and that of p53, p= 0.06. Conclusion: High-grade muscle-invasive Schistosomal associated urothelial carcinomas are common, but with limited CD44 and p53 co-expression.
Keywords
Muscle invasive; urothelial carcinoma; p53; CD44; high grade
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