Syzygium cumini (L) Extract Ameliorates Aluminium Chloride-Induced Acute Hepatic and Renal Toxicity in Rats | ||||
| Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology | ||||
| Article 6, Volume 13, Issue 2, December 2021, Page 73-87 PDF (857.62 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/eajbsc.2021.196250 | ||||
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| Author | ||||
| Fatma Elzahraa Hussien Salem | ||||
| Zoology and entomology department, Faculty of Science, Helwan University, Cairo, Egypt. | ||||
| Abstract | ||||
| Aluminium (Al) is the most common metallic element associated with pathogenesis in humans and animals. This study was conducted to evaluate the ability of Syzygium cumini (L.) leaves extract in attenuating the acute toxicity of aluminium-induced hepatic and renal toxicity in rats. Male rats were received oral administration of AlCl3 (150mg/kg) followed by oral administration of S. cumini (250mg/kg) leaves extract for 14 days. Aluminium concentration, MDA, NO, glutathione, oxidative enzymes (catalase, superoxide dismutase, glutathione reductase and glutathione peroxidase) was measured in liver and kidney homogenate. In addition, we demonstrate the level of serum and liver AST, ALT, ALP and serum urea and creatinine. Compared to the control group, the animal that received Al showed a significant elevation in the tissue level of Al, MDA, NO and reduction in the level of glutathione and antioxidant enzymes. It also showed a marked increase in serum liver function enzymes, creatinine and urea. The combined treatment with S. cumini leaves extract caused restoration of the oxidative levels and upregulation in antioxidant enzymes as compared to Al-intoxicated rats. In addition, the administration of S. cumini extracts in rats after Al administration caused a decrease in cytokines TNF-α and IL- 6, Bax & caspase-3 expression, in addition, to an increase in antiapoptotic marker Bcl2 in liver and kidney homogenate. In conclusion, our study revealed that the treatment with S. cumini leaves extracts ameliorates hepatic and renal cells toxicity produced by Al exposure by elevating the antioxidant enzymes, antiapoptotic and anti-inflammatory activity. | ||||
| Keywords | ||||
| Syzygium cumini (L.); Aluminium; antioxidant; antiapoptotic; liver; kidney | ||||
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