Genetic variation in adiposity related genes and risk for breast cancer in postmenopausal women
fawzy, A., gomaa, A., aldaly, M., hefzi, N., nawzr, N. (2022). Genetic variation in adiposity related genes and risk for breast cancer in postmenopausal women. EKB Journal Management System, 28(1), 63-73. doi: 10.21608/zumj.2021.88030.2298
amal fawzy; abdelazeem gomaa; mai aldaly; nabila hefzi; nashwa nawzr. "Genetic variation in adiposity related genes and risk for breast cancer in postmenopausal women". EKB Journal Management System, 28, 1, 2022, 63-73. doi: 10.21608/zumj.2021.88030.2298
fawzy, A., gomaa, A., aldaly, M., hefzi, N., nawzr, N. (2022). 'Genetic variation in adiposity related genes and risk for breast cancer in postmenopausal women', EKB Journal Management System, 28(1), pp. 63-73. doi: 10.21608/zumj.2021.88030.2298
fawzy, A., gomaa, A., aldaly, M., hefzi, N., nawzr, N. Genetic variation in adiposity related genes and risk for breast cancer in postmenopausal women. EKB Journal Management System, 2022; 28(1): 63-73. doi: 10.21608/zumj.2021.88030.2298

Genetic variation in adiposity related genes and risk for breast cancer in postmenopausal women

Zagazig University Medical Journal
Article 8, Volume 28, Issue 1, January 2022, Page 63-73  XML PDF (314.29 K)
Document Type: Original Article
DOI: 10.21608/zumj.2021.88030.2298
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Authors
amal fawzy email 1; abdelazeem gomaa2; mai aldaly3; nabila hefzi4; nashwa nawzr4
1alkhshat street
2medical biochemistry ,faculty of medicine,zagazig university
3medical biochemisyrt,faculty of medicine,zagazig university
4clinical oncology and nucluar medicine,faculty of medicine,zagazig university
Abstract
ABackground: Breast cancer is the most common malignancy in women . Obesity has been linked to an increased risk of developing a number of malignancies, including postmenopausal breast cancer. The link between obesity and breast cancer involves elevated estrogen production and adipokines secretion that affect tumorigenesis.
Objective: We investigated whether genetic variations in the Leptin (LEP) and CYP19A1 genes are associated with risk of breast cancer among Egyptian postmenopausal women.
Methods: This is a case control study. It included 112 postmenopausal breast cancer patients and 112 healthy postmenopausal controls .The LEP(-2548G>A) and CYP19A1 (rs10046C/T) gene polymorphisms were determined using polymerase chain reaction-based restriction fragment length polymorphism and Tetra Amplification refractory mutation system - polymerase chain reaction ,respectively.
Results: Significant difference between postmenopausal breast cancer women and controls regarding allele and genotype distributions of LEP(-2548G>A) (OR 1.8 , 95 % CI 1.23–2.73 and p=0.007 for A allele) and CYP19A1 (rs10046C/T) polymorphisms (OR 1.9, 95 % CI 1.27–3.8, and p = 0.004 for T allele). Moreover, stratified analysis of these polymorphisms in relation to body mass index revealed interactive effect between LEP (-2548G>A) and BMI for the breast cancer risk.
Conclusion: The results suggest that the AA genotype and A allele of leptin polymorphism, as well as the TT genotype and T allele of the CYP19A1 polymorphism, may be associated with increased risk of the development of breast cancer, Moreover obese postmenopausal breast cancer patients carrying LEP A allele have 3 fold risk to develop breast cancer in the Egyptian population.
Keywords
Leptin; adiposity; CYP191A; polymorphism; breast cancer
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