Integrated Use of Nanomechanical, Histological, and Biochemical Biomarkers of Oreochromis niloticus as a Signature of Metal Stress
Salem, H., Hagras, A., El-Baghdady, H., El-Naggar, A. (2021). Integrated Use of Nanomechanical, Histological, and Biochemical Biomarkers of Oreochromis niloticus as a Signature of Metal Stress. EKB Journal Management System, 23(1), 35-43. doi: 10.21608/cat.2021.196721
Hamada Salem; Ahmed E Hagras; Heba Allah M El-Baghdady; Ahmed M El-Naggar. "Integrated Use of Nanomechanical, Histological, and Biochemical Biomarkers of Oreochromis niloticus as a Signature of Metal Stress". EKB Journal Management System, 23, 1, 2021, 35-43. doi: 10.21608/cat.2021.196721
Salem, H., Hagras, A., El-Baghdady, H., El-Naggar, A. (2021). 'Integrated Use of Nanomechanical, Histological, and Biochemical Biomarkers of Oreochromis niloticus as a Signature of Metal Stress', EKB Journal Management System, 23(1), pp. 35-43. doi: 10.21608/cat.2021.196721
Salem, H., Hagras, A., El-Baghdady, H., El-Naggar, A. Integrated Use of Nanomechanical, Histological, and Biochemical Biomarkers of Oreochromis niloticus as a Signature of Metal Stress. EKB Journal Management System, 2021; 23(1): 35-43. doi: 10.21608/cat.2021.196721

Integrated Use of Nanomechanical, Histological, and Biochemical Biomarkers of Oreochromis niloticus as a Signature of Metal Stress

Catrina: The International Journal of Environmental Sciences
Article 4, Volume 23, Issue 1, August 2021, Page 35-43  XML PDF (880.24 K)
Document Type: Original Article
DOI: 10.21608/cat.2021.196721
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Authors
Hamada Salem email orcid ; Ahmed E Hagras; Heba Allah M El-Baghdady; Ahmed M El-Naggar
Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt
Abstract
The invasion of fish by heavy metals is a recognized environmental problem. Heavy metals, after leaking into the water, penetrate fish directly through the gill and later the skin. Fish develops protective defense mechanisms against the damaging effects of heavy metals. This study was aimed to investigate the concentrations of certain metals (cadmium, iron, manganese, cobalt, and lead) in the muscle tissues of the Nile tilapia (Oreochromis niloticus) and their possible impact on its histological, nanomechanical, and biochemical biomarkers. The results showed that fish muscle from the polluted site contained high levels of heavy metals compared to the reference site. Biochemical profile of the Nile tilapia showed that serum glucose, total proteins, uric acid, creatinine, bilirubin, superoxide dismutase, and malondialdehyde were elevated in exposed tilapia compared to their corresponding reference. Histological examination of the liver showed severe alterations in the liver tissue. Nanomechanical properties (roughness and stiffness) confirmed the damaging effect of metals on the liver tissue. These findings provide a rational application of histological, nanomechanical and biochemical parameters to be used as indicators of metal stress. Integrated biomarker response is a comprehensive index of all biomarkers and a good indicator of the health status of aquatic ecosystem.
Keywords
Heavy metals; Antioxidants; nanomechanical; Oxidative Stress; Integrated Biomarker Response
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