Release mechanisms for profen-loaded nanofibers: Challenges and opportunities
fattahi, F., ZAMANI, T. (2021). Release mechanisms for profen-loaded nanofibers: Challenges and opportunities. EKB Journal Management System, 4(4), 195-213. doi: 10.21608/jabps.2021.72197.1126
farnaz-sadat fattahi; TAHEREH ZAMANI. "Release mechanisms for profen-loaded nanofibers: Challenges and opportunities". EKB Journal Management System, 4, 4, 2021, 195-213. doi: 10.21608/jabps.2021.72197.1126
fattahi, F., ZAMANI, T. (2021). 'Release mechanisms for profen-loaded nanofibers: Challenges and opportunities', EKB Journal Management System, 4(4), pp. 195-213. doi: 10.21608/jabps.2021.72197.1126
fattahi, F., ZAMANI, T. Release mechanisms for profen-loaded nanofibers: Challenges and opportunities. EKB Journal Management System, 2021; 4(4): 195-213. doi: 10.21608/jabps.2021.72197.1126

Release mechanisms for profen-loaded nanofibers: Challenges and opportunities

Journal of advanced Biomedical and Pharmaceutical Sciences
Article 2, Volume 4, Issue 4, October 2021, Page 195-213  XML PDF (2.51 MB)
Document Type: Review Articles
DOI: 10.21608/jabps.2021.72197.1126
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Authors
farnaz-sadat fattahi email orcid 1; TAHEREH ZAMANIorcid 2
1Isfahan university of technology,ISFAHAN,IRAN
2University of social welfare and rehabilitation sciences, THE GENETIC RESEARCH CENTER
Abstract
Nanofibrous meshes refer to the structures made of ultra-fine polymeric fibers. Because of nanometer measure size with an excessive strength/weight ratio, they are actual suitable as a nanosystem for delivering drug molecules. Drug molecules which mixed in nanofibers, can be released from the surrounding environment by means of various mechanisms in different manners (burst release, sustainable release and tunable release). Nanofibers can be used by way of release rate controlling strategies as proper delivery structures for drug molecules.The objective of this review is to highpoint the capacity of nanofibers as novel releasing substances for profens (Propionic acid derivative drugs including Carprofen; Naproxen; Fenoprofen; Flurbiprofen; Ibuprofen; Ketoprofen and Tiaprofenic acid). The profens are a class of nonselective, nonsteroidal anti-inflammatory drugs (NSAIDs). These drug molecules are derivatives of 2-phenylpropanoic acid. All contain a chiral center resulting in the formation of two enantiomers (R and S) of each profen.
In this review, full information will be reported about the new progresses for release behaviors of profen molecules form the novel nanofibrous delivery systems. The drug releasing kinetics of profen molecules from nanofibers will be described briefly. The authors use more than 80 articles , books and thesis published in the case of nanofibrous profens delivery and releasing systems.
Keywords
Nanofibers; Release characteristic; propionic acid derivative drugs; kinetic; sustainable release
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