Current Trends and Future Perspectives of Hydrogen Sulfide Donors | ||||
| Journal of advanced Biomedical and Pharmaceutical Sciences | ||||
| Article 5, Volume 4, Issue 4, October 2021, Page 231-245 PDF (780.85 K) | ||||
| Document Type: Review Articles | ||||
| DOI: 10.21608/jabps.2021.80739.1131 | ||||
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| Authors | ||||
Aya Shabib1; Mai Shoman1; Elshimaa Mohamed Naguib Abdelhafez  2; Gamal Abou=Rahma3
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| 1Medicinal Chemistry Department, Faculty of Pharmacy, Minia University. | ||||
| 2Associate professor at Medicinal chemistry department Minia university | ||||
| 3Medicinal Chemistry Department, Faculty of Pharmacy, Minia University | ||||
| Abstract | ||||
| ABSTRACT: Hydrogen sulfide (H2S) gas is included to be the most critical endogenous gasotransmitters that has several pathophysiological effects in many human cells and organ tissues. The synthesis of endogenous H2S in cells via several pathways. Variant biological effects of H2S including ion channel regulation, redox regulation of protein, thiols, polysulfides, thiosulfate/sulfite, and anti-oxidant activities affecting many cellular and molecular reactions. Therefore, it is essential to review H2S chemical biology, methods of detection of H2S release and its effects on pathological and physiological functions along with their therapeutic uses, including cardiovascular protective activities, anti-inflammatory and anti-tumor activities of the H2S donors. | ||||
| Keywords | ||||
| Keywords: Hydrogen sulfide (H2S); gasotransmitters; donors; anticancer; hybrids | ||||
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