Soluble Transferrin Receptor - Ferritin Indices as Diagnostic Tool for Iron Deficiency Anemia in Chronic Kidney Disease in Children | ||||
| Zagazig University Medical Journal | ||||
| Article 12, Volume 30, Issue 4, July and August 2024, Page 1124-1132 PDF (779.97 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2021.60279.2112 | ||||
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| Authors | ||||
Esraa Hassan  1; Hatem Hussein1; Naglaa Khalifa2; Ezzat Kamel1
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| 1Department of Pediatrics, Faculty of Medicine – Zagazig University, Zagazig, Sharkia, Egypt. | ||||
| 2Clinical pathology, Faculty of medicine , Zagazig university ,Egypt | ||||
| Abstract | ||||
| Background: Anemia is common complication in childern with chronic kidney disease (CKD) mainly anemia of chronic disease (ACD), but iron deficiency anemia (IDA) is also common. Soluble transferrin receptor (sTfR) is important marker for IDA, Objective: to evaluate the utility of soluble transferrin Receptor-Ferritin Indices as markers of IDA and for differentiation ACD from IDA in childern with chronic kidney disease , Patient and methods: cross-sectional study was conducted at Department of Pediatric Nephrology at Zagazig University Hospital including 45 anemic children (19 ACD, 13 IDA and 13 mixed). The duration of the study ranges from 6 to 12 months, Soluble serum transferrin receptor and Soluble serum transferrin receptor index were measured. Results: There was no significant difference among groups regard age or weight distribution. There was no significant difference regard sex distribution among studied groups. regard sTfR and sTfR index IDA group were significantly higher than other two groups then mixed and finally ACD were significantly lower. Conclusion: sTfR value was useful tool for assessment of iron status in patients with CKD, however, they are at best complementary to the existing indices of serum ferritin and TSAT. | ||||
| Keywords | ||||
| Keywords: Anemia; Anemia Of Chronic Disease; Ferritin; Iron Deficiency Anemia; Soluble Transferrin Receptor | ||||
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