Fibronectin, but not laminin, expression is associated with favorable outcomes in breast cancer patients
Kamal, M., El-Gerbed, M., Talaat, A., Abdul-aziz, K., Shalaby, A., Khedr, R., Salem, M. (2021). Fibronectin, but not laminin, expression is associated with favorable outcomes in breast cancer patients. EKB Journal Management System, 5(4), 135-145. doi: 10.21608/jcbr.2021.63387.1176
Mohamed Kamal; Mohamed El-Gerbed; Aml Talaat; Karoline Abdul-aziz; Ahmed Shalaby; Rasha Khedr; Mohamed Salem. "Fibronectin, but not laminin, expression is associated with favorable outcomes in breast cancer patients". EKB Journal Management System, 5, 4, 2021, 135-145. doi: 10.21608/jcbr.2021.63387.1176
Kamal, M., El-Gerbed, M., Talaat, A., Abdul-aziz, K., Shalaby, A., Khedr, R., Salem, M. (2021). 'Fibronectin, but not laminin, expression is associated with favorable outcomes in breast cancer patients', EKB Journal Management System, 5(4), pp. 135-145. doi: 10.21608/jcbr.2021.63387.1176
Kamal, M., El-Gerbed, M., Talaat, A., Abdul-aziz, K., Shalaby, A., Khedr, R., Salem, M. Fibronectin, but not laminin, expression is associated with favorable outcomes in breast cancer patients. EKB Journal Management System, 2021; 5(4): 135-145. doi: 10.21608/jcbr.2021.63387.1176

Fibronectin, but not laminin, expression is associated with favorable outcomes in breast cancer patients

Egyptian Journal of Cancer and Biomedical Research
Article 11, Volume 5, Issue 4, December 2021, Page 135-145  XML PDF (7.39 MB)
Document Type: Original Article
DOI: 10.21608/jcbr.2021.63387.1176
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Authors
Mohamed Kamalorcid 1; Mohamed El-Gerbed2; Aml Talaat2; Karoline Abdul-aziz2; Ahmed Shalaby3; Rasha Khedr4; Mohamed Salemorcid 5
1Stem Cell and Regenerative Medicine Norris Comprehensive Cancer Center Keck School of Medicine University of Southern California (USC) Room 3514, Norris Research Tower, 1441 Eastlake Ave, Los Angeles, UAS.
2Department of Zoology, Faculty of Science, Damanhour University, Damanhour, Egypt.
3Department of Oncologic Pathology, Damanhour National Medical Institute, Damanhour, El-Behera, Egypt.   Pathology Department, Faculty of Medicine, Nagasaki University, Japan.  
4 Department of clinical Oncology, Faculty of Medicine, Tanta University, Tanta, Egypt. 
5Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt.
Abstract
Background: The biology of breast cancer was shown to vary in different ethnic populations. Fibronectin (FN) and laminin (LN) are adhesive glycoproteins present in the extracellular matrix (ECM) and have been shown to associate with prognosis of breast cancer patients. However, their prognostic values have not been fully studied. Aim: We aim to study the prognostic values of FN and LN in breast cancer patients. Materials and Methods: Here, we used immunohistochemical (IHC) staining to investigate the expression patterns of FN and LN in 77 breast cancer patients and to evaluate their prognostic values. Results: High expression levels of FN and LN were detected in 72.7% and 67.5% of cases, respectively. High FN expression was associated with longer overall survival (OS) and disease-free survival (DFS). Moreover, multivariate analysis showed that FN is an independent prognostic factor for OS and DFS. No significant associations detected between LN expression and clinicopathological parameters or survival data. Conclusion: Our results suggest that FN and LN biomarkers biologically function differently in breast cancer.
Keywords
reast cancer; Fibronectin; immunohistochemistry; Laminin; Prognostic marker
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