New microextraction methods for the evaluation of bromhexine HCl in pure and pharmacological formulations. | ||||
| Egyptian Journal of Chemistry | ||||
| Article 21, Volume 65, Issue 4, April 2022, Page 209-219 PDF (795.45 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2021.92380.4377 | ||||
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| Authors | ||||
Nagham Khairi Kareem  1; mohammed zabon thani2; Khalid F. Al-Rawi3
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| 1Department of Chemistry,University of Anbar,Al-Anbar,Iraq | ||||
| 2Al-Mustansiriyah University | ||||
| 3Department of Chemistry, College of Science, University of Anbar , Iraq | ||||
| Abstract | ||||
| In this study, ion-pair reactions were used to investigate bromhexine HCl. The development of simple, accurate, sensitive, low-cost, and efficient extraction methods for bromohexine HCl separation, such as the DLLME and cloud point extraction techniques, are described as bromhexine HCl estimation methodologies. These methods employed the interaction of bromohexine HCl with alizarin yellow reagent to produce a yellow complex in an acidic medium (pH = 5). The complex's maximum absorbance intensity was 480 nm, and the stoichiometry for both continuous variation and molar ratio methods was determined to be 1:1. The dispersive liquid liquid microextraction (DLLME) method's concentration range (1-23µg.mL-1), the Beers law was obeyed with correlation coefficient (R2=0.998), limit of detection as (0.055µg.mL-1), limit of quantification as (0.183µg.mL-1) and molar absorptivity as (23930.2L.mol-1.cm-1).In the second technique, the cloud pointextraction method, The linearity of calibration curve above was the range between (1-40 µg.mL-1), the correlation coefficient (R2=0.998) and molar absorptivity was (13202.88L.mol-1.cm-1), (LOD) and (LOQ) were (0.141µg.mL-1) and (1.4641µg.mL-1), respectively. The proposed techniques can be used for the determination of bromohexine HCl in both pure and pharmaceutical formulations with very good success and pharmaceutical formulations with very good success. | ||||
| Keywords | ||||
| Bromhexine HCl (BRH); DLLME; Cloud point extraction; spectrophotometer | ||||
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