Urinary monocyte chemotactic protein 1 as a predictive marker of steroid responsiveness in children with idiopathic nephrotic syndrome
El hamshary, A., Abdel Haie, O., Afifi, W., El Falah, A., Mohammed, A. (2021). Urinary monocyte chemotactic protein 1 as a predictive marker of steroid responsiveness in children with idiopathic nephrotic syndrome. EKB Journal Management System, 6(5), 51-54. doi: 10.21608/bjas.2021.198228
A.S. El hamshary; O.M. Abdel Haie; W.E Afifi; A.A. El Falah; A.R. Mohammed. "Urinary monocyte chemotactic protein 1 as a predictive marker of steroid responsiveness in children with idiopathic nephrotic syndrome". EKB Journal Management System, 6, 5, 2021, 51-54. doi: 10.21608/bjas.2021.198228
El hamshary, A., Abdel Haie, O., Afifi, W., El Falah, A., Mohammed, A. (2021). 'Urinary monocyte chemotactic protein 1 as a predictive marker of steroid responsiveness in children with idiopathic nephrotic syndrome', EKB Journal Management System, 6(5), pp. 51-54. doi: 10.21608/bjas.2021.198228
El hamshary, A., Abdel Haie, O., Afifi, W., El Falah, A., Mohammed, A. Urinary monocyte chemotactic protein 1 as a predictive marker of steroid responsiveness in children with idiopathic nephrotic syndrome. EKB Journal Management System, 2021; 6(5): 51-54. doi: 10.21608/bjas.2021.198228

Urinary monocyte chemotactic protein 1 as a predictive marker of steroid responsiveness in children with idiopathic nephrotic syndrome

Benha Journal of Applied Sciences
Article 9, Volume 6, Issue 5, September 2021, Page 51-54  XML PDF (425.78 K)
Document Type: Original Research Papers
DOI: 10.21608/bjas.2021.198228
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Authors
A.S. El hamshary1; O.M. Abdel Haie1; W.E Afifi1; A.A. El Falah2; A.R. Mohammed1
1Pediatrics, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt
2Clinical and Chemical Pathology, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt
Abstract
Background: The role of pro-inflammatory cytokines in the immunopathogenesis of idiopathic nephrotic syndrome (INS)  had been widely postulated. Reports on the release of cytokines, during idiopathic nephrotic syndrome activation, were conflicting in defining a specific interleukin pattern during relapse and remission of the disease. The monocyte chemoattractant protein-1 (MCP-1) is a member of the CC chemokine family, and a potent chemotactic factor for monocytes. It plays an important role in the recruitment of monocytes/macrophages into renal tubulointerstitium . Objective: The aim of this study was to determine the urinary level of monocyte chemotactic protein-1 (uMCP-1) in idiopathic nephrotic syndrome patients and its relationship to steroid sensitivity. Patients and Methods: This cross sectional study included 40 patients with nephrotic syndrome (NS) following up in Pediatric Nephrology Clinic, Benha University subdivided into 2 groups: group A (cases in remission) & group B (cases in activity). Also, 20 age and sex matched healthy children have been included as a control group. Results:  We found a highly significant difference in urinary MCP-1 between group A, group B, and controls, the highest being group B. The levels in patients in remission still exceeded the controls significantly. No difference was found between males and females in group A as regards urinary MCP-1 levels yet females had significantly higher levels in group B. This difference was not seen in controls. Conclusions: Urinary MCP-1 is highly sensitive and specific biomarker in idiopathic nephrotic syndrome.
Keywords
Idiopathic Nephrotic Syndrome; Urinary Monocyte Chemotactic Protein-1; Relapse; Remission
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