Evaluation of the effect of PRF on bone healing in diabetic animals after periradicular surgery

mohammed, mohammed saad; elkhawas, moataz bellah; gobran, hany Gameil; islam, taher medhat

doi:10.21608/ajdsm.2020.45472.1122

	Evaluation of the effect of PRF on bone healing in diabetic animals after periradicular surgery
Al-Azhar Journal of Dental Science
Article 5, Volume 24, Issue 4, October 2021, Page 379-385 PDF (406.86 K)
Document Type: Original Article
DOI: 10.21608/ajdsm.2020.45472.1122
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Authors
mohammed saad mohammed ¹; moataz bellah elkhawas ²; hany Gameil gobran³; taher medhat islam ⁴
¹endodontic department, faculty of dentistry, al azhar university, Cairo,egypt
²department of endodontics, faculty of dentistry, Al Azhar University,Cairo Egypt
³Department of oral biology, Faculty of Dentistry, Al-Azhar University, Cairo,egypt
⁴Department of Endodontics, Faculty of Dentistry, Al-Azhar University, Cairo,egypt
Abstract
Objective: was directed to evaluate platelet rich fibrin alone and in combination with xenograft as an alternative to bone substitute in treatment of critical sized bone defects in dogs. Material and methods:8 dogs were selected for this study in which diabetes mellitus was induced. Root canal treatment was done in the 2nd and 4th premolar teeth of both sides then 4 critical sized bone defects were created in relation to the distal root of the selected teeth. According to the bone cavity filling materials there was 4 groups xenograft, xenograft and PRF, PRF and blood clot groups. Dogs were sacrificed at 4 days,2,5and 9 weeks the mandibles were harvested for DEXA evaluation. Results: bone density measurement at 9 weeks was significant with Xenograft and PRF group than Xenograft, PRF and blood clot groups, and at the same time there was no significance between Xenograft and PRF groups. Conclusion: PRF is a valuable material that can be used as a sole grafting material in periradicular surgery to improve bone regeneration.
Keywords
PRF; periradicular surgery; PRF sole grafting material; PRF and Xenograft combination


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