Effects of obesity-related inflammatory markers on psychosomatic manifestations of premenstrual tension syndrome: towards better therapeutic outcomes (An original article)
Mariah, R., El-Dardiry, S., Mahmoud, H., Mabrouk, M., El-Dardiry, N., Aly, H., Omran, F., Nabo, M., Soliman, T., Abdel-Gawad, A., Baiomy, N., Yousef, R., Mohammed, N., El Sayed, S., Elsemary, M., Abdel-Latif, H. (2022). Effects of obesity-related inflammatory markers on psychosomatic manifestations of premenstrual tension syndrome: towards better therapeutic outcomes (An original article). EKB Journal Management System, 5(1), 11-25. doi: 10.21608/svuijm.2021.91586.1211
Reham A. Mariah; Samia A. El-Dardiry; Heba A. Mahmoud; Mohamed M Mabrouk; Nawal A. El-Dardiry; Hanan Yousef Aly; Faten M. Omran; Manal Mohamed Helmy Nabo; Tamer M Soliman; Abdelhady Ragab Abdel-Gawad; Nivin Baiomy; Reda S Yousef; Nesreen Ali Mohammed; Salah Mohamed El Sayed; MA Elsemary; Hytham Mahmoud Abdel-Latif. "Effects of obesity-related inflammatory markers on psychosomatic manifestations of premenstrual tension syndrome: towards better therapeutic outcomes (An original article)". EKB Journal Management System, 5, 1, 2022, 11-25. doi: 10.21608/svuijm.2021.91586.1211
Mariah, R., El-Dardiry, S., Mahmoud, H., Mabrouk, M., El-Dardiry, N., Aly, H., Omran, F., Nabo, M., Soliman, T., Abdel-Gawad, A., Baiomy, N., Yousef, R., Mohammed, N., El Sayed, S., Elsemary, M., Abdel-Latif, H. (2022). 'Effects of obesity-related inflammatory markers on psychosomatic manifestations of premenstrual tension syndrome: towards better therapeutic outcomes (An original article)', EKB Journal Management System, 5(1), pp. 11-25. doi: 10.21608/svuijm.2021.91586.1211
Mariah, R., El-Dardiry, S., Mahmoud, H., Mabrouk, M., El-Dardiry, N., Aly, H., Omran, F., Nabo, M., Soliman, T., Abdel-Gawad, A., Baiomy, N., Yousef, R., Mohammed, N., El Sayed, S., Elsemary, M., Abdel-Latif, H. Effects of obesity-related inflammatory markers on psychosomatic manifestations of premenstrual tension syndrome: towards better therapeutic outcomes (An original article). EKB Journal Management System, 2022; 5(1): 11-25. doi: 10.21608/svuijm.2021.91586.1211

Effects of obesity-related inflammatory markers on psychosomatic manifestations of premenstrual tension syndrome: towards better therapeutic outcomes (An original article)

SVU-International Journal of Medical Sciences
Article 3, Volume 5, Issue 1, January 2022, Page 11-25  XML PDF (661.64 K)
Document Type: Original research articles
DOI: 10.21608/svuijm.2021.91586.1211
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Authors
Reham A. Mariah1; Samia A. El-Dardiry1; Heba A. Mahmoud2; Mohamed M Mabrouk3; Nawal A. El-Dardiry4; Hanan Yousef Aly5; Faten M. Omran6; Manal Mohamed Helmy Nabo7; Tamer M Soliman8; Abdelhady Ragab Abdel-Gawad8; Nivin Baiomy9; Reda S Yousef10; Nesreen Ali Mohammed11; Salah Mohamed El Sayed email 12; MA Elsemary13; Hytham Mahmoud Abdel-Latif6
1Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Egypt
2Department of Pharmacology, Faculty of Medicine, Tanta University, Egypt
3Department of Internal Medicine, Faculty of Medicine, Tanta University, Egypt
4Department of Obstetrics & Gynaecology, Faculty of Medicine, Tanta University, Egypt
5Department of Neuropsychiatry, Faculty of Medicine, Sohag University, Egypt
6Department of Pharmacology, Faculty of Medicine, Sohag University, Egypt
7Division of Pediatric Cardiology, Department of Pediatrics, Hail directorate of Health, Hail, Saudi Arabia & Sohag Teaching Hospital, Sohag, Egypt.
8Department of Clinical Pathology, Faculty of Medicine, Sohag University, Egypt
9Department of Clinical Pathology, Faculty of Medicine, Tanta University, Egypt
10Department of Medical Biochemistry, Faculty of Medicine, Sohag University, Egypt
11Department of Public Health and Community Medicine, Faculty of Medicine, Sohag University, Egypt
12Department of Medical Biochemistry, Faculty of Medicine, Sohag University, Egypt & Department of Clinical Biochemistry, Taibah Faculty of Medicine, Taibah University, Saudi Arabia.
13Department of Obstetrics & Gynaecology, Faculty of Medicine, Sohag University, Egypt
Abstract
Background: Obesity-induced inflammation facilitates depression and premenstrual tension syndrome. Hypoxia is a common feature of inflammation. Hypoxia inducible factors adapt cells to low oxygen tension and inflammation.
Objectives: We aimed to see how obesity, along with Amiloride, Hydrochlorothiazide, Metformin, calorie restriction, and walking exercise, affected psychosomatic characteristics of premenstrual tension syndrome, during a six-month period.
Patients and methods: A prior ethical committee approval and informed patients’ consent were taken. This study was performed in Tanta University, Egypt from May 2019 to December 2019. This study aims at evaluating the effects of obesity-induced inflammatory mediators on psychosomatic effects in women having premenstrual tension syndrome. Effects of combined therapy using (Metformin, Amiloride.  Hydrochloride/ Hydrochlorthiazide,  caloric restriction, half an hour of walking exercise per day, and Vitazinc capsules) treatment was compared to the same combined therapy including Royal vitamin G treatment (instead of Vitazinc) on alleviating psychosomatic manifestations of premenstrual tension syndrome. Sixty obese women having premenstrual tension syndrome were categorized into younger age group (18-39 years) and older age (40-48 years) versus a non-obese age-matched control 
group. Body mass index in addition to serum tumour necrosis factor-α (TNF- α), hypoxia-inducible factor-1α (HIF-1α) and receptor activator of nuclear factor- kappa-Β ligand (RANKL) were assessed. Related psychosomatic manifestations of premenstrual tension syndrome (edema, anxiety, and fatigue) were also assessed.
Results: Obesity significantly increased serum TNF-α (p < 0.01), HIF-1 α (p < 0.01) and RANKL (p < 0.01). Obesity-induced biochemical effects were higher in older obese women than younger ones. Obesity significantly exaggerated the severity of investigated psychosomatic manifestations (p < 0.001). Both combined therapies (including either Vitazinc or Royal vitamin G) significantly and dramatically decreased the percentage of cases having psychosomatic manifestations (p < 0.001) that was closely related to the decreased serum biochemical parameters.
Conclusion: Combined therapy containing Royal vitamin G significantly improved serum biochemical parameters and psychosomatic manifestations better than combined therapy containing Vitazinc.
Keywords
premenstrual tension syndrome; psychosomatic manifestations; anxiety; royal vitamin G and Vitazinc
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