ASSOCIATION OF NEUROPEPTIDE-Y -399 (T/C) GENE POLYMORPHISM AND ITS LEVEL WITH THE RISK OF TYPE-2 DIABETES MELLITUS | ||||
| The Egyptian Journal of Biochemistry and Molecular Biology | ||||
| Article 3, Volume 36, Issue 1, December 2018, Page 49-67 PDF (405.8 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejb.2018.19851 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Yasser Elghobashy  1; Eman Abd El Gayed2; Shimaa Zewin3
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| 1Medical Biochemistry,Faculty of Medicine, Menoufia University, Egypt | ||||
| 2Medical Biochemistry, Faculty of Medicine, Menoufia University, Egypt | ||||
| 3Internal Medicine Departments Faculty of Medicine, Menoufia University, Egypt | ||||
| Abstract | ||||
| Neuropeptide-Y (NPY) is widely distributed centrally and peripherally and plays an important role in regulating glucose metabolism, energy metabolism and vascular function. Several studies had found that NPY is involved in the pathophysiology of type-2 diabetes Mellitus (T2DM). The aim of this study was to evaluate the association of NPY -399 (T/C) gene polymorphism and its serum level with susceptibility to T2DM. Seventy diabetic patients and seventy age and gender matched healthy controls were enrolled in this study. Serum NPY was measured by ELISA and NPY rs16147(-399 T/C) polymorphism was analyzed using the TaqMan allelic discrimination assay technique. Results showed significant statistical differences between the two studied groups regarding serum NPY level and NPY rs16147 (-399T/C) genotype distribution with increased serum NPY level and increased frequency of the CC and TC genotype in patients with diabetes mellitus. Conclusion: CC genotypes of NPY (-399 T/C) gene polymorphism and its associated high serum NPY level might be a genetic risk factor for T2DM. | ||||
| Keywords | ||||
| Type-2 diabetes mellitus; neuropeptide-Y; Insulin Resistance; Gene polymorphism | ||||
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