T-lymphocyte subsets (CD3+, CD4+, and CD8+) in Systemic Lupus Erythematosus (SLE): Correlation with Clinical Manifestation
El-Maghraby, A., Ali, Y., El-maadawy, E., Elshal, M., Bassyouni, I., El-Garawani, I., Talaat, R. (2021). T-lymphocyte subsets (CD3+, CD4+, and CD8+) in Systemic Lupus Erythematosus (SLE): Correlation with Clinical Manifestation. EKB Journal Management System, 7(3), 116-129. doi: 10.21608/jbaar.2021.198735
Abeer M. El-Maghraby; Yasser B.M. Ali; Eman A. El-maadawy; Mohamed F. Elshal; Iman H Bassyouni; Islam M El-Garawani; Roba M. Talaat. "T-lymphocyte subsets (CD3+, CD4+, and CD8+) in Systemic Lupus Erythematosus (SLE): Correlation with Clinical Manifestation". EKB Journal Management System, 7, 3, 2021, 116-129. doi: 10.21608/jbaar.2021.198735
El-Maghraby, A., Ali, Y., El-maadawy, E., Elshal, M., Bassyouni, I., El-Garawani, I., Talaat, R. (2021). 'T-lymphocyte subsets (CD3+, CD4+, and CD8+) in Systemic Lupus Erythematosus (SLE): Correlation with Clinical Manifestation', EKB Journal Management System, 7(3), pp. 116-129. doi: 10.21608/jbaar.2021.198735
El-Maghraby, A., Ali, Y., El-maadawy, E., Elshal, M., Bassyouni, I., El-Garawani, I., Talaat, R. T-lymphocyte subsets (CD3+, CD4+, and CD8+) in Systemic Lupus Erythematosus (SLE): Correlation with Clinical Manifestation. EKB Journal Management System, 2021; 7(3): 116-129. doi: 10.21608/jbaar.2021.198735

T-lymphocyte subsets (CD3+, CD4+, and CD8+) in Systemic Lupus Erythematosus (SLE): Correlation with Clinical Manifestation

Journal of Bioscience and Applied Research
Article 3, Volume 7, Issue 3, September 2021, Page 116-129  XML PDF (409.44 K)
Document Type: Original Article
DOI: 10.21608/jbaar.2021.198735
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Authors
Abeer M. El-Maghraby1; Yasser B.M. Ali2; Eman A. El-maadawy2; Mohamed F. Elshal2; Iman H Bassyouni3; Islam M El-Garawani1; Roba M. Talaat email orcid 2
1Zoology Department, Faculty of Science, Menoufia University, Shebin El-Kom 32511, Menoufia, Egypt
2Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt
3Rheumatology and Rehabilitation Department, Faculty of Medicine, Cairo University, Cairo, Egypt
Abstract
AIM: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that has a multifactorial etiology. T- Lymphocytes are essential in SLE pathogenesis. It plays a crucial role in autoantibody production and the subsequent immune complex formation, which may induce or directly damage multiple organs. This study was carried out aiming to quantify certain T lymphocyte subsets (CD3+, CD4+, and CD8+) in SLE patients and to elucidate if there is a possible influence of disease activity scores and clinical manifestations. Patients and Methods: This study included 100 SLE patients with various disease activity scores (SLEDAI) and 100 healthy age and sex-matched controls. The frequency of CD3+, CD4+, and CD8+ was assessed by flow cytometry. Results: A significant up-regulation in CD3+ (P<0.01), CD8+ (P<0.001) coincides with a significant downregulation in CD4+cells (P<0.001) were detected in SLE patients compared to controls. A significant up-regulation in CD4+ (P<0.05) was demonstrated in active SLE patients compared with the inactive form of the disease. On the other hand, no significant change was observed in the frequency of CD3+ and CD8+T cell subsets between active and inactive patients. Arthritic patients have a significant reduction in CD3+ and CD4+ T cells while those with Vasculities significantly reduce in CD4+, CD8+ compared with SLE patients without these manifestations.   Conclusion: The current study results stressed the importance of T cell subsets in SLE disease. They might participate in disease activity and in controlling several manifestations of lupus. Our findings will help design more studies on the role of T cell subsets in SLE pathogenesis which may provide new therapeutic targets for SLE.
Keywords
SLE; T-lymphocyte; CD3+, CD4+, CD8+
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