Therapeutic effect of folic acid supplementation on type 2 diabetic rat model | ||||
| Zagazig University Medical Journal | ||||
| Article 1, Volume 31, Issue 1.1, January 2025, Page 1-6 PDF (913.17 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2021.89280.2312 | ||||
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| Authors | ||||
Mariam Nasr Michael  1; Maher Nageb Ibrahim2; ebtisam mohamed ebrahim2; nanees fouad elmalkey3
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| 1Physiology department, Faculty of Medicine, Zagazig University | ||||
| 2physiology department ,zagazig university | ||||
| 3physiology,faculty of medicine,zagazig university,zagazig,Egypt | ||||
| Abstract | ||||
| Background: type 2 diabetes (DM2)is associated with high risk of microvascular and macrovascular comorbidities. Many micronutrients are involved in combating DM and its complication. Aim of the study: To investigate the effects of Folic acid in albino rats model of DM2. Materials and Methods: Thirty male adult albino rats were divided randomly into 3 groups control, diabetes mellitus (DM2): DM2 was induced by 4 weeks of high fat diet then streptozotocin (25 mg/kg/ i.p, once), and Folic acid-treated DM2 with (5mg/kg b.w) orally for 8 weeks. Serum glucose, Insulin, Lipid profile, CRP were analyzed, HOMA-IR, and plasma atherogenic Index (AIP) were calculated. Results: In Folic acid-treated DM2 group, there was a significant decrease in serum glucose, HOMA-IR, cholesterol, triglyceride, AIP, CRP with significant increase in serum insulin and high density lipoprotein when compared to DM2 group. Conclusion: Use of folic acid was effective in a rat model of DM which is owed to its reducing gluco-metabolic disturbances, antioxidant, anti-inflammatory roles. Key words: Folic acid, Diabetes mellitus type 2. | ||||
| Keywords | ||||
| Folic acid; Diabetes mellitustype 2; obesity | ||||
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