Teratogenic effect of fluconazole on rabbit’s foeti | ||||
| Mansoura Veterinary Medical Journal | ||||
| Articles in Press, Accepted Manuscript, Available Online from 12 October 2021 | ||||
| Document Type: Original Articles | ||||
| DOI: 10.21608/mvmj.2021.92503.1077 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Sara Elazab  1; sally I ibrahim2; Magdy Salah Amer3; Gehan N Gad4; Rasha A ElGalil5
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| 1Department of Pharmacology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt | ||||
| 2animal health research institute, Mansoura | ||||
| 3Pharmacology Department, Faculty of veterinary medicine, Mansoura university | ||||
| 4Animal health research institute, Zagazig | ||||
| 52Department of Pharmacology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, Egypt | ||||
| Abstract | ||||
| Objective: The current study was designed to assess the teratogenic effect of fluconazole on developing rabbits’ foeti Design: Randomized controlled study. Animals: Twenty-four sexually mature females and 2 adult males New Zealand white rabbits, 5- 6 months old, weighing 3-4 kg, were used in this study. The mature males were used for mating process Procedure: The pregnant female rabbits (24) were allotted into 4 groups (6 rabbits/ group). Control group (G1) administered normal saline. Other groups were given fluconazole orally at a dose 80 mg/kg once daily for ten days either on the first stage (G2), the second stage (G3), or the third stage (G4) of gestation period. Three dams were sacrificed from every group (n=3) on the 20th and 30th day of gestation. The influence of fluconazole on the developing foeti was investigated grossly and histopathologically. Results: Administration of fluconazole during gestation caused significant reduction (P < 0.05) in the mean values of viable foeti, fetal body weight and crown-rump length, and significant elevation (P < 0.05) in the mean values of dead foeti, fetal resorption rate, pre- and post-implantation death. Additionally, visceral fetal abnormalities were noticed including; thickened ventricles of the heart, and dilated lateral ventricles of brain. Moreover, fluconazole induced skeletal anomalies in the developing foeti shown as absence of last rib. Conclusion and clinical relevance: The prescription of fluconazole must be prevented during pregnancy to avoid fetal malformations. | ||||
| Keywords | ||||
| Fluconazole; Rabbits; Teratology; Fetal abnormalities | ||||
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