Potential Toxic Effects of Aluminum Nanoparticles: An overview
Elkhadrawy, B., Abou-Zeid, S., El-Borai, N., El-Sabbagh, H., El-Bialy, B. (2021). Potential Toxic Effects of Aluminum Nanoparticles: An overview. EKB Journal Management System, 3(2), 94-106. doi: 10.21608/jcvr.2021.199440
Basma Elkhadrawy; Shaimaa Abou-Zeid; Nermeen El-Borai; Hesham El-Sabbagh; Badr El-Said El-Bialy. "Potential Toxic Effects of Aluminum Nanoparticles: An overview". EKB Journal Management System, 3, 2, 2021, 94-106. doi: 10.21608/jcvr.2021.199440
Elkhadrawy, B., Abou-Zeid, S., El-Borai, N., El-Sabbagh, H., El-Bialy, B. (2021). 'Potential Toxic Effects of Aluminum Nanoparticles: An overview', EKB Journal Management System, 3(2), pp. 94-106. doi: 10.21608/jcvr.2021.199440
Elkhadrawy, B., Abou-Zeid, S., El-Borai, N., El-Sabbagh, H., El-Bialy, B. Potential Toxic Effects of Aluminum Nanoparticles: An overview. EKB Journal Management System, 2021; 3(2): 94-106. doi: 10.21608/jcvr.2021.199440

Potential Toxic Effects of Aluminum Nanoparticles: An overview

Journal of Current Veterinary Research
Article 11, Volume 3, Issue 2, October 2021, Page 94-106  XML PDF (347.94 K)
Document Type: Original Article
DOI: 10.21608/jcvr.2021.199440
View on SCiNiTO View on SCiNiTO
Authors
Basma Elkhadrawy1; Shaimaa Abou-Zeid1; Nermeen El-Borai1; Hesham El-Sabbagh1; Badr El-Said El-Bialy email orcid 2
1Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, University of Sadat City, 32897.
2Department of Forensic Medicine and Toxicology, University of Sadat City, Sadat City, Egypt
Abstract
Alumina (aluminum oxide) nanoparticles (AlNPs) have been categorized among the most important nano-metals, with wide applications in many fields as in food, agriculture, industry, engineering, pharmacy, medicine and others. The extensive use of AlNPs results in a massive release of them into the environment resulting in potential adverse impacts on animals and human health. Toxicokinetic studies demonstrated the rapid absorption and the systemic distribution of AlNPs to different organs. AlNPs mainly induced their toxic damage by induction of oxidative stress and mitochondrial dysfunction. Cellular accumulation of AlNPs resulted in interaction with cell components and binding with proteins and genetic materials (DNA and RNA) with producing other different chemical compounds resulting in cellular oxidative damage. Also, AlNPs induced cell death by disrupting the integrity of the mitochondrial membrane, depleting the mitochondrial thiols, activating apoptotic caspases (9 and 3) and generating more ROS. Previous in vivo and in vitro studies revealed hepato-, nephro-, myocardial, reproductive and neuro-toxic effects of AlNPs. Moreover, AlNPs exert inflammatory, apoptotic and geno-toxic effects. The aim here is to spot on previous studies demonstrating the toxic effects of AlNPs.

Keywords
alumina nanoparticles; hepatotoxicity; nephrotoxicity; neurotoxicity; oxidative stress
Statistics
Article View: 510
PDF Download: 656