Green Synthesis, Cytotoxicity and Antimicrobial Activities of Some New Pyrazolines, Pyrimidines and Naphthyridines Based on 1,3-Di(thien-2-yl)prop-2- en-1-one Using Choline Chloride-Urea Mixture As A Deep Eutectic Solvent
Mohamed, E., Abdelmajeid, A., Behalo, M., Abel-Maaboud, A., Hebaish, K. (2022). Green Synthesis, Cytotoxicity and Antimicrobial Activities of Some New Pyrazolines, Pyrimidines and Naphthyridines Based on 1,3-Di(thien-2-yl)prop-2- en-1-one Using Choline Chloride-Urea Mixture As A Deep Eutectic Solvent. EKB Journal Management System, 65(4), 651-663. doi: 10.21608/ejchem.2021.95621.4488
Enas A Mohamed; Abdelmotaal Abdelmajeid; Mohamed Behalo; Ali Abel-Maaboud; Kaouser Hebaish. "Green Synthesis, Cytotoxicity and Antimicrobial Activities of Some New Pyrazolines, Pyrimidines and Naphthyridines Based on 1,3-Di(thien-2-yl)prop-2- en-1-one Using Choline Chloride-Urea Mixture As A Deep Eutectic Solvent". EKB Journal Management System, 65, 4, 2022, 651-663. doi: 10.21608/ejchem.2021.95621.4488
Mohamed, E., Abdelmajeid, A., Behalo, M., Abel-Maaboud, A., Hebaish, K. (2022). 'Green Synthesis, Cytotoxicity and Antimicrobial Activities of Some New Pyrazolines, Pyrimidines and Naphthyridines Based on 1,3-Di(thien-2-yl)prop-2- en-1-one Using Choline Chloride-Urea Mixture As A Deep Eutectic Solvent', EKB Journal Management System, 65(4), pp. 651-663. doi: 10.21608/ejchem.2021.95621.4488
Mohamed, E., Abdelmajeid, A., Behalo, M., Abel-Maaboud, A., Hebaish, K. Green Synthesis, Cytotoxicity and Antimicrobial Activities of Some New Pyrazolines, Pyrimidines and Naphthyridines Based on 1,3-Di(thien-2-yl)prop-2- en-1-one Using Choline Chloride-Urea Mixture As A Deep Eutectic Solvent. EKB Journal Management System, 2022; 65(4): 651-663. doi: 10.21608/ejchem.2021.95621.4488

Green Synthesis, Cytotoxicity and Antimicrobial Activities of Some New Pyrazolines, Pyrimidines and Naphthyridines Based on 1,3-Di(thien-2-yl)prop-2- en-1-one Using Choline Chloride-Urea Mixture As A Deep Eutectic Solvent

Egyptian Journal of Chemistry
Article 58, Volume 65, Issue 4, April 2022, Page 651-663  XML PDF (361.94 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2021.95621.4488
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Authors
Enas A Mohamed email 1; Abdelmotaal Abdelmajeidorcid 2; Mohamed Behalo3; Ali Abel-Maaboud4; Kaouser Hebaish3
1Chemistry department, faculty of science, benha university
2Chemistry Department, Faculty of Science, Benha University, Benha, Egypt.
3chemistry department, faculty of science, benha university
4Chemistry Department, Faculty of Science, Benha University, Benha, Egypt
Abstract
An efficient and facile green synthesis of chalcone derivatives 1a-d was achieved by treatment of aromatic aldehydes with 2-acetylthiophene in the presence of choline chloride-urea mixture as a deep eutectic solvent. Chalcone 1a was used as a reactive key precursor to design a series of bio-active heterocycles such as pyrimidine, pyrazoline, pyridine, pyridopyrimidine and naphthyridine. The Structural formula of derivatives were confirmed and characterized by their elemental analyses and spectral data (IR, MS, 1H NMR, 13C NMR). In addition, the synthesized derivatives were evaluated for their antimicrobial activities, it was found that compounds 3, 8 and 9a exhibited potent antifungal activity in comparison with the standard drug. Cytotoxicity against breast cancer (MCF7) was screened also and most compounds showed low to moderate activity. The results of the viral screening against HBV of selected compounds indicated that compounds (9b, 15), 8, (3, 6), and 5 showed moderate viral replication inhibition.
Keywords
Chalcone; deep eutectic solvent; pyrazoline; pyrimidine; antitumor activity; antimicrobial activity
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