Synthesis of Some New Fused Pyridines and Prediction their Biological Activity via PASS INET. | ||||
Journal of Pharmaceutical and Applied Chemistry | ||||
Volume 1, Issue 2, September 2015, Page 28-34 PDF (450.68 K) | ||||
Document Type: Original Article | ||||
DOI: 10.12785/jpac/010202 | ||||
View on SCiNiTO | ||||
Authors | ||||
A. M. El-Sayed; H. Abdel-Ghany; A. A. Amer; A. M. Ahmed. | ||||
Chemistry Department, Faculty of Science, Sohag 82524, Egypt. | ||||
Abstract | ||||
A new series of fused heterocyclic compounds containing pyridine moieties were prepared via the reaction of 2-amino-6-(methylthio)-4-phenylpyridine-3,5-dicarbonitrile with some halo reagents, active methylenes, acetic anhydride, phenylisothiocyanate, hydrazine hydrate or thioacetamide. Accompanied with Predictions of the activity spectra of some selected compounds using PASS INET.at Pa > 70%, showing high probability of Atherosclerosis treatment, Antineoplastic, DNA intercalator, Protein kinase inhibitor and Signal transduction pathways inhibitor. | ||||
Keywords | ||||
phase transfer catalysis; pyridine; pyrrole; pyrimidine; pyrrazole; fused pyridine; PASS INET | ||||
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