Radiolabelling and Biological Assessment of 99mTc-Mebeverine as a Possible Tracer for Solid Tumor Diagnosis
Essam, H., Refaye, M., El-Sharawy, D. (2021). Radiolabelling and Biological Assessment of 99mTc-Mebeverine as a Possible Tracer for Solid Tumor Diagnosis. EKB Journal Management System, 34(1), 21-26. doi: 10.21608/ejrsa.2021.92163.1122
Heba M. Essam; Marwa S. Refaye; Dina M. El-Sharawy. "Radiolabelling and Biological Assessment of 99mTc-Mebeverine as a Possible Tracer for Solid Tumor Diagnosis". EKB Journal Management System, 34, 1, 2021, 21-26. doi: 10.21608/ejrsa.2021.92163.1122
Essam, H., Refaye, M., El-Sharawy, D. (2021). 'Radiolabelling and Biological Assessment of 99mTc-Mebeverine as a Possible Tracer for Solid Tumor Diagnosis', EKB Journal Management System, 34(1), pp. 21-26. doi: 10.21608/ejrsa.2021.92163.1122
Essam, H., Refaye, M., El-Sharawy, D. Radiolabelling and Biological Assessment of 99mTc-Mebeverine as a Possible Tracer for Solid Tumor Diagnosis. EKB Journal Management System, 2021; 34(1): 21-26. doi: 10.21608/ejrsa.2021.92163.1122

Radiolabelling and Biological Assessment of 99mTc-Mebeverine as a Possible Tracer for Solid Tumor Diagnosis

Egyptian Journal of Radiation Sciences and Applications
Article 3, Volume 34, Issue 1, December 2021, Page 21-26  XML PDF (1.54 MB)
Document Type: Original Article
DOI: 10.21608/ejrsa.2021.92163.1122
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Authors
Heba M. Essam1, 2; Marwa S. Refaye email 1, 3; Dina M. El-Sharawy1, 4
1Cyclotron Project, Nuclear Research Centre, Egyptian Atomic Energy Authority, Cairo, Egypt
2Biological Application Department, Nuclear Research Center, Egyptian Atomic Energy Authority, Cairo, Egypt
3Radioactive isotopes and generators department, Hot Lab. Center, Egyptian Atomic Energy Authority, Cairo, Egypt
4Labeled Compounds Department, Hot Lab. Center, Egyptian Atomic Energy Authority, Cairo, Egypt
Abstract
NUCLEAR medicine is one the most important fields to inspect and treat tumors by radiation or by introducing labeled radiopharmaceuticals, which are in the spot of our interest. In this study, the authors investigated the possibility of using mebeverine as a solid tumor marker. Mebeverine was labeled with Technetium (99mTc-Meb) reaching a radiochemical yield (RCY) of 97% via a reduction reaction using SnCl2. The tracer showed a high stability in the serum for 12 hours which is essential to avoid any undesired accumulations in the non-target organs. Its bioevaluation in normal and induced tumored mice was performed to identify the capability of the use of the tracer for the diagnosis of solid tumors. The uptake by the tumor was 14.2% after 30 min of injection and increased to 18.5%, viewing a decline after 3 hours, this could be attributed to that washout to the tumored muscle extravasation. Tumored /Non-Tumored (T/NT) ratio was applied, the ratio reached 3.14 which shows the selectivity of 99mTc-Meb to the solid tumor induced in the right thigh.
Keywords
Mebeverine; Serum stability; Solid tumor; 99mTc; T/NT ratio; Tumored mice
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