Design, Synthesis and Hypolipidemic Activity of Novel Hydrazones of Nicotinic acid Hydrazide
O. Aboelez, M., M. Elhady, O., S. A. Shaykoon, M., E.Shoman, M., A. Ahmed, S., A. Abuo-Rahma, G. (2016). Design, Synthesis and Hypolipidemic Activity of Novel Hydrazones of Nicotinic acid Hydrazide. EKB Journal Management System, 2(3), 39-43. doi: 10.18576/jpac/020304
Moustafa O. Aboelez; Omar M. Elhady M. Elhady; Montaser S. A. Shaykoon; Mai E.Shoman; Sanaa A. Ahmed; Gamal El-Din A. Abuo-Rahma. "Design, Synthesis and Hypolipidemic Activity of Novel Hydrazones of Nicotinic acid Hydrazide". EKB Journal Management System, 2, 3, 2016, 39-43. doi: 10.18576/jpac/020304
O. Aboelez, M., M. Elhady, O., S. A. Shaykoon, M., E.Shoman, M., A. Ahmed, S., A. Abuo-Rahma, G. (2016). 'Design, Synthesis and Hypolipidemic Activity of Novel Hydrazones of Nicotinic acid Hydrazide', EKB Journal Management System, 2(3), pp. 39-43. doi: 10.18576/jpac/020304
O. Aboelez, M., M. Elhady, O., S. A. Shaykoon, M., E.Shoman, M., A. Ahmed, S., A. Abuo-Rahma, G. Design, Synthesis and Hypolipidemic Activity of Novel Hydrazones of Nicotinic acid Hydrazide. EKB Journal Management System, 2016; 2(3): 39-43. doi: 10.18576/jpac/020304

Design, Synthesis and Hypolipidemic Activity of Novel Hydrazones of Nicotinic acid Hydrazide

Journal of Pharmaceutical and Applied Chemistry
Volume 2, Issue 3, September 2016, Page 39-43  XML PDF (372.42 K)
Document Type: Original Article
DOI: 10.18576/jpac/020304
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Authors
Moustafa O. Aboelez1; Omar M. Elhady M. Elhady2; Montaser S. A. Shaykoon3; Mai E.Shoman4; Sanaa A. Ahmed5; Gamal El-Din A. Abuo-Rahma5
11Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, 61519-Egypt. 2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, Sohag, 82524-Egypt.
2Department of Chemistry, Faculty of Science, Sohag University, Sohag, 82524-Egypt.
3Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-AzharUniversity, Assiut, 71524-Egypt.
4Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, 61519-Egypt.
5Department of Pharmacology, Faculty of Medicine, Sohag University, Sohag, 82524-Egypt.
Abstract
Synthesis of novel N-acyl hydrazones of nicotinic acid hydrazide via condensation of nicotinic acid hydrazide 3 with the corresponding aldehydes 1, 2 are described. Their hypolipidemic activities were evaluated in high cholesterol diet fed rat model. The hydrazones were found to decrease the levels of serum total cholesterol, LDL cholesterol and triglycerides in hyperlipidemic rats to a greater degree than the reference gemfibrozil.

Keywords
2-Tosyloxybenzaldehyde; 4-Tosyloxybenzaldehyde; Fibrates; Cholesterol; Triglycerides and Hypolipidemia
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