The In-vitro Antimicrobial and Antioxidant Activities of some Diels-Alder Diaryl Methanone Adducts | ||||
| Journal of Pharmaceutical and Applied Chemistry | ||||
| Volume 3, Issue 1, January 2017, Page 46-53 PDF (688.2 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.18576/jpac/030102 | ||||
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| Author | ||||
| Ganesamoorthy Thirunarayanan | ||||
| Department of Chemistry, Annamalai University, Annamalainagar-608 002, India. | ||||
| Abstract | ||||
| The in-vitro antimicrobial and antioxidant activities of some 2-(9H-fluorene-2-yl)-3-(substituted phenyl)bicyclo [2.2.1]hept-5-ene-2-yl methanones by disc-diffusion as well as serial dilution against their microbial strains and DPPH radical scavenging activities. The titled substrates were synthesized by environmentally benign water mediated Diels-Alder reaction of 9H-2-fluorenyl chalcones and cyclopentadiene in good yields. Conclusion: The present results confirm the positive correlation between the acute phase response of inflammation and oxidative stress in non-diabetic and diabetic obese subjects. | ||||
| Keywords | ||||
| In-vitro antimicrobial activity; Antioxidant activity; Diels-Alder adduct; Environmentally benign reaction | ||||
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