Value of antifungal susceptibility testing in recurrent vulvovaginal Candidiasis by Non -Albicans Candida | ||||
| Egyptian Journal of Medical Microbiology | ||||
| Article 20, Volume 30, Issue 1, January 2021, Page 161-167 PDF (257.64 K) | ||||
| Document Type: New and original researches in the field of Microbiology. | ||||
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| Author | ||||
Ghada Abd el moniem Mokhtar 
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| Department of Medical Microbiology and Immunology, Faculty of Medicine, Zagazig University | ||||
| Abstract | ||||
| Background: Vulvovaginal candidiasis (VVC) is regarded as a prevalent vaginal infection and mainly results fromCandida albicans. Nevertheless, there has recently been a prominent shift in candidiasis etiology regarding non-albicans Candida (NAC) species with achieving importance. For women with more than three episodes annually are described as recurrent vulvovaginal candidiasis (RVVC). Objectives: To isolate, speciate, and determine the value of antifungal sensitivity pattern of candida species isolated from patients developed (RVVC). Methodology: High vaginal swabs (HVS) were taken from patients with RVVC and cultured on ordinary mycological media. Any significant candida growth was identified and speciated byVITEK 2 system. Their antifungal sensitivity was done by disc diffusion approach governed by CLSI guidelines. Results: A total of 110 Candida species from 250 high vaginal swabs were isolated. Among all candida species isolated from patients with RVCC, C.albicanis accounts for 44% while NAC accounts for 56% with C.glabrata most common species isolated. Voriconazole, amphotericin B, and nystatin showed high sensitivity rates (92 %, 89%, and 84% respectively) on all candida species (C.albicans and NAC) isolated from patients with RVVC. Conclusion: In RVCC there is increase in NAC (56%) with C.glabrata most common species isolated. Voriconazole, Nystatin, and amphotericin B have the best antifungal activity against all spp. | ||||
| Keywords | ||||
| Vulvovaginal candidiasis; Recurrent vulvovaginal candidiasis; non-albicans Candida; Antifungal sensitivity | ||||
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