Therapeutic Efficacy of Kumquat-Loaded Chitosan Nanoparticles against Toxoplasmosis in mice model | ||||
| Egyptian Journal of Chemistry | ||||
| Article 61, Volume 65, Issue 2, February 2022, Page 609-622 PDF (932.51 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2021.100354.4663 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Wafaa Abd El-Hamed1; Nahed Samy2; Ahmed Abd-Rabou   3; Zainab Salem4
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| 1a.Biological and Environmental Sciences Dept., Faculty of Home Economics, Al-Azhar University, Egypt | ||||
| 2bFood Science and Technology Dept., Faculty of Home Economics, Al-Azhar University, Egypt | ||||
| 3cHormones Department, Medical Research Division, and Stem Cell Laboratory, Center of Excellence for Advanced Science, National Research Centre, 12622, Giza, Egypt. | ||||
| 4dNutrition and Food ScienceDept., Faculty of Home Economics, Al-Azhar University, Egypt. | ||||
| Abstract | ||||
| The goal of this study was to compare the effects of kumquat extract and its chitosan nanoparticles on biochemical, histopathological, and parasitological factors in mice infected with Toxoplasma gondii versus spiramycin and control groups. A total of 35 mice, 7 of which were negative control and 28 was infected group, were used in the current study. All mice were sacrificed at 45 day after inoculation. Blood samples were collected. Then, sera Malondialdehyde (MDA), Catalase (CAT), Superoxide Dismutase 3 (SOD3), α-glutathione S-transferases (α-GST), and Interleukin 6 (IL-6) concentrations were measured using ELISA technique. In infected groups, CAT, SOD3, α-GST levels were decreased significantly (P | ||||
| Keywords | ||||
| Toxoplasma gondii; Oxidative stress; Kumquat; Chitosan nanoparticles | ||||
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