Design and Synthesis of Hydrazide-Hydrazones Based 2-Oxonicotinonitrile Derivatives as Potential Antimicrobial Agents
El-Sayed, H., Moustafa, A., Awad, H., Abd El-Moneim, M., Esmat, A. (2018). Design and Synthesis of Hydrazide-Hydrazones Based 2-Oxonicotinonitrile Derivatives as Potential Antimicrobial Agents. EKB Journal Management System, 4(2), 53-59. doi: 10.18576/jpac/040207
H. A. El-Sayed; A. H. Moustafa; H. M. Awad; M. Abd El-Moneim; A. Esmat. "Design and Synthesis of Hydrazide-Hydrazones Based 2-Oxonicotinonitrile Derivatives as Potential Antimicrobial Agents". EKB Journal Management System, 4, 2, 2018, 53-59. doi: 10.18576/jpac/040207
El-Sayed, H., Moustafa, A., Awad, H., Abd El-Moneim, M., Esmat, A. (2018). 'Design and Synthesis of Hydrazide-Hydrazones Based 2-Oxonicotinonitrile Derivatives as Potential Antimicrobial Agents', EKB Journal Management System, 4(2), pp. 53-59. doi: 10.18576/jpac/040207
El-Sayed, H., Moustafa, A., Awad, H., Abd El-Moneim, M., Esmat, A. Design and Synthesis of Hydrazide-Hydrazones Based 2-Oxonicotinonitrile Derivatives as Potential Antimicrobial Agents. EKB Journal Management System, 2018; 4(2): 53-59. doi: 10.18576/jpac/040207

Design and Synthesis of Hydrazide-Hydrazones Based 2-Oxonicotinonitrile Derivatives as Potential Antimicrobial Agents

Journal of Pharmaceutical and Applied Chemistry
Volume 4, Issue 2, May 2018, Page 53-59  XML PDF (554.75 K)
Document Type: Original Article
DOI: 10.18576/jpac/040207
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Authors
H. A. El-Sayed1; A. H. Moustafa1; H. M. Awad2; M. Abd El-Moneim3; A. Esmat3
1Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt.
2Department of Tanning Materials and Leather Technology, National Research Centre, Dokki 12622, Cairo, Egypt.
3Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt.
Abstract
Synthesis and antimicrobial screening of new series of hydrazide-hydrazones were described. Where, regiospacific alkylation of 2-oxonicotinonitriles1a,b with ethyl bromoacetate followed by hydrozinolys is afforded acetic acid hydrazides3a,b. The latter compounds were condensed with a variety of carbonyl containing compounds to give the target compounds of hydrazide- hydrazone derivatives 4a,b, 5a,b and6a-h. While, reaction of 3 a,b with acetyl acetone gave pyrazole derivatives7a,b. The antimicrobial activity of the new synthesized compounds 4b, 5c, 5e and 6bshowed a good activity against tested fungi (Aspergillus niger), while, all the tested compounds have a good and moderate activity against G (+ve) and G (-ve) bacteria.

Keywords
2-Oxonicotinonitrile; Hydrazide-hydrazone; Antimicrobial
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